中国药理学与毒理学杂志2026，Vol.40Issue(5)：363-372,10.DOI:10.3867/j.issn.1000-3002.2026.08716
二甲双胍治疗神经病理性疼痛作用机制研究进展
Research progress in mechanisms of metformin against neuropathic pain
摘要
Abstract
Neuropathic pain(NP),also known as neurogenic pain,is a form of chronic pain caused by damage to or disease of the somatosensory nervous system.Research suggests that metformin,a classic antidiabetic drug,holds therapeutic potential in the field of pain management.However,its specific targets and the interactive network between these multiple targets remain unclear.This paper reviews the latest research findings about how this drug alleviates NP through adenosine monophosphate-acti-vated protein kinase(AMPK),downstream AMPK signalling molecules and their interaction networks,and the mammalian target of rapamycin complex 1(mTORC1).Based on analysis of the mechanisms and variations in therapeutic efficacy,the advantages of and challenges to metformin in the treatment of NP are summarized while a biomarker-based,stratified precision analgesic strategy is recommended,which is expected to provide a framework for optimizing dosing regimens,developing targeted interven-tions for NP,and implementing personalized pain management.关键词
二甲双胍/神经源性疼痛/精准化疼痛管理/个性化/镇痛/生物标志物Key words
metformin/neuropathic pain/precision pain management/personalize/analgesia/bio-marker分类
医药卫生引用本文复制引用
冉钊旭,徐晓英,王娜,阎文军..二甲双胍治疗神经病理性疼痛作用机制研究进展[J].中国药理学与毒理学杂志,2026,40(5):363-372,10.基金项目
甘肃省联合科研基金重点项目(25JRRA1199) （25JRRA1199）
甘肃省重点人才项目(2023RCXM13) （2023RCXM13）
甘肃省联合科研基金一般项目(25JRRA1203) （25JRRA1203）
甘肃省重点研发计划(23YF-FA00460) （23YF-FA00460）
甘肃省科技计划(21JR7RA675) （21JR7RA675）
兰州市科技局医疗卫生专项(2023-1-47) Gansu Provincial Joint Research Fund Key Project(25JRRA1199) （2023-1-47）
Gansu Provincial Key Talent Proj-ect(2023RCXM13) （2023RCXM13）
Gansu Provincial Joint Research Fund General Project(25JRRA1203) （25JRRA1203）
Gansu Provincial Key R&D Program(23YFFA00460) （23YFFA00460）
Gansu Provincial Science and Technology Plan Project(21JR7RA675) （21JR7RA675）
and Lanzhou Munici-pal Science and Technology Bureau Healthcare Special Project(2023-1-47) （2023-1-47）
