中国合理用药探索2026，Vol.23Issue(5)：107-112,6.DOI:10.3969/j.issn.2096-3327.2026.05.015
羟考酮复合神经阻滞对髋部骨折患者术后镇痛效果、关节功能恢复及早期炎性因子水平的影响
Efficacy of Oxycodone Combined with Nerve Block on Postoperative Analgesia,Joint Function Recovery and Early Inflammatory Factor Levels in Patients with Hip Fracture
摘要
Abstract
Objective:To investigate the effects of oxycodone combined with nerve block on postoperative analgesia,joint function recovery and early inflammatory factor levels in patients with hip fracture.Methods:A prospective clinical study was conducted on 100 patients with hip fracture scheduled for hip surgery in our hospital from February 2023 to April 2025.Patients were randomly divided into two groups using block randomization:group A(n=50)received nerve block anesthesia alone,and group B(n=50)received oxycodone combined with nerve block anesthesia.Dynamic and resting pain intensity[Visual Analogue Scale(VAS)],postoperative joint range of motion,postoperative functional recovery,early inflammatory factor levels and adverse reactions were compared between the two groups.Results:The dynamic VAS score at 24 h after operation and resting VAS score at 6 h after operation in group B were lower than those in group A(P<0.05).The flexion and abduction degrees at 48 h and 72 h after operation in both groups were higher than those at 24 h after operation(P<0.05),and those in group B were higher than those in group A at 24 h and 48 h after operation(P<0.05).The time to first straight leg raise≥10 cm,time to first ambulation and timed up and go test(TUG)time at 72 h after operation in group B were shorter than those in group A(P<0.05).At 1 day after operation,interleukin-6(IL-6),interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α)in both groups were increased(P<0.05),but those in group B were lower than those in group A(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups during postoperative hospitalization(P>0.05).Conclusion:Oxycodone combined with nerve block can significantly enhance postoperative analgesia,promote early recovery of joint function,inhibit postoperative inflammatory response in patients with hip fracture,without increasing the risk of adverse reactions.关键词
髋部骨折/羟考酮/神经阻滞/关节功能/炎性因子Key words
hip fracture/oxycodone/nerve block/joint function/inflammatory factors分类
医药卫生引用本文复制引用
汪力新,崔魁,李永强,蒋刚健,李宪营..羟考酮复合神经阻滞对髋部骨折患者术后镇痛效果、关节功能恢复及早期炎性因子水平的影响[J].中国合理用药探索,2026,23(5):107-112,6.基金项目
恩泽疼痛管理医学研究项目(ezmr2022-077) （ezmr2022-077）
