中国合理用药探索2026，Vol.23Issue(5)：135-140,6.DOI:10.3969/j.issn.2096-3327.2026.05.019
长期服用第二代抗精神病药物的精神分裂症患者肝损伤程度的危险因素分析及预测模型构建
Analysis of Risk Factors and Construction of Prediction Model for Liver Injury in Schizophrenia Patients Taking Long-Term Second-Generation Antipsychotics
摘要
Abstract
Objective:To analyze the risk factors for the degree of liver injury in schizophrenia patients taking long-term second-generation antipsychotics,and to construct a risk prediction model for severe liver injury.Methods:Clinical data of 80 schizophrenia patients admitted to our hospital from January 2023 to December 2024 were retrospectively analyzed.According to the degree of liver injury,they were divided into mild group(n=41),moderate group(n=25)and severe group(n=14).Clinical data including gender,age,body mass index(BMI),disease duration,schizophrenia subtype,diabetes,hypertension,coronary heart disease,drinking history,smoking history,anemia,malnutrition and types of drugs were compared among the three groups.Indicators with statistical significance in univariate analysis were included in Logistic regression model.Receiver operating characteristic(ROC)curve was used to construct a risk prediction model for severe liver injury based on the combined data fitted by regression coefficients.Results:Univariate analysis showed that age,BMI,disease duration,drinking history,malnutrition and types of drugs were the main suspected risk factors affecting the degree of liver injury.Further Logistic regression analysis showed that BMI,malnutrition and types of drugs were independent risk factors for severe liver injury(P<0.05).ROC curve analysis of the combined model showed that the area under the curve(AUC)was 0.892,the prediction sensitivity was 99.2%,the specificity was 78.8%,the prediction accuracy was 50.0%,the recall rate was 99.5%,and the prediction probability was 0.82.Conclusion:Age,BMI,disease duration,drinking history,malnutrition and types of drugs are the main suspected risk factors for liver injury in schizophrenia patients taking long-term second-generation antipsychotics,among which BMI,malnutrition and types of drugs are independent risk factors for severe liver injury.Clinical monitoring and management of the above factors should be strengthened to reduce the occurrence of drug-induced liver injury.关键词
长期服用/第二代抗精神病药物/精神分裂症/肝损伤/危险因素/预测模型Key words
long-term administration/second-generation antipsychotics/schizophrenia/liver injury/risk factors/prediction model分类
医药卫生引用本文复制引用
赵中健,刘文静,刘志华,朱俊敬..长期服用第二代抗精神病药物的精神分裂症患者肝损伤程度的危险因素分析及预测模型构建[J].中国合理用药探索,2026,23(5):135-140,6.基金项目
2024年度郑州市医学科研项目(ZZYK2024067) （ZZYK2024067）
