中国中药杂志2026，Vol.51Issue(9)：2417-2427,11.DOI:10.19540/j.cnki.cjcmm.20260209.304
基于多重平行打击学说的柴胡活性成分干预代谢相关脂肪性肝病的研究进展
Research progress on intervention of active components of Bupleuri Radix in metabolic dysfunction-associated fatty liver disease based on multiple parallel strike theory
摘要
Abstract
Metabolic dysfunction-associated fatty liver disease(MAFLD)is a prevalent chronic liver disease worldwide.Due to its complex pathogenesis,there is currently no specific drug capable of intervening throughout the entire pathological process,nor a unified and definitive treatment protocol in clinical practice.In traditional Chinese medicine,MAFLD falls under the category of diseases such as"hypochondriac pain"and"liver disease",with the core pathogenesis being"stagnation of the liver meridian and obstruction of Qi movement".The pharmacological characteristics of Bupleuri Radix(BR),which"soothes the liver,relieves stagnation,and promotes Qi movement",are highly consistent with this pathogenesis.Furthermore,data mining studies have shown that BR is among the most frequently used herbs in TCM clinical protocols for treating MAFLD,and its herb pairs and classic formulas have demonstrated favorable therapeutic effects in clinical application.Modern pharmacological studies have also confirmed that BR is rich in active ingredients,including saponins(e.g.,saikosaponin A/D/B2),volatile oils(e.g.,D-limonene,hexanoic acid),flavonoids(e.g.,quercetin,rutin,kaempferol),and polysaccharides.These active ingredients can target multiple pathological aspects of the"multiple parallel hits"in MAFLD,such as improving insulin resistance(IR),alleviating endoplasmic reticulum stress(ERS),repairing mitochondrial function,regulating oxidative stress(OS)response,modulating intestinal microbiota imbalance,and inhibiting inflammasome activation,thereby slowing the progress of MAFLD.Its mechanism of action is closely related to the regulation of PI3K/Akt,PPAR,Nrf2,AMPK,MAPK,PINK1/Parkin,NLRP3 inflammasome and the"gut-liver axis",reflecting the integrative regulatory advantages of TCM's multi-component,multi-target and multi-mechanism approach.Future in-depth studies should focus on precise component profiling of BR,validation of key targets,and the synergistic mechanisms within"formula-component"interactions to better leverage the value of BR in the prevention and treatment of MAFLD.关键词
代谢相关脂肪性肝病/柴胡/活性成分/中医药/作用机制Key words
metabolic dysfunction-associated fatty liver disease/Bupleuri Radix/active ingredients/traditional Chinese medicine/mechanism of action引用本文复制引用
王俊皓,苏苗,张秋菊,刘迎,陈世玉,刘文晶,曹郡薇,赵鲲鹏..基于多重平行打击学说的柴胡活性成分干预代谢相关脂肪性肝病的研究进展[J].中国中药杂志,2026,51(9):2417-2427,11.基金项目
国家自然科学基金项目(81660772) （81660772）
甘肃省中医药管理局科研课题(GZK-2018-2) （GZK-2018-2）
甘肃中医药大学"岐黄英才"导师专项基金项目(ZYXKBD-202413) （ZYXKBD-202413）
甘肃中医药大学研究生创新创业基金项目(2026CXCY-271) （2026CXCY-271）
