中国中药杂志2026，Vol.51Issue(9)：2428-2437,10.DOI:10.19540/j.cnki.cjcmm.20260203.801
当归有效成分治疗溃疡性结肠炎的研究进展
Research progress on treatment of ulcerative colitis with active ingredients of Angelicae Sinensis Radix
摘要
Abstract
Ulcerative colitis(UC)is a complex chronic inflammatory disease.It is characterized by a prolonged and persistent clinical course,accompanied by a rising tendency in the risk of colorectal cancer.The incidence of UC continues to rise,with a complex etiology and a lack of effective therapeutic agents.TCM has unique advantages in the prevention and treatment of UC,due to its multi-target regulation properties,multi-pathway action,mild side effects,and diverse pharmacological activities.Angelicae Sinensis Radix(AS)contains various active components,including angelica polysaccharides,volatile oils,and organic acids.These components can alleviate UC by a multi-target regulation mechanism,including the inhibition of NF-κB,NLRP3 inflammasome activation,the reduction of the expression of inflammatory factors such as TNF-α and IL-1β,the enhancement of antioxidant enzyme activity,and the up-regulation of tight junction proteins such as ZO-1 and Occludin.Such multi-pathway synergistic effects fully highlight the preventive and therapeutic advantages of TCM,demonstrating the potential application value of AS in the treatment of intestinal diseases.This review systematically elucidated the multidimensional anti-UC mechanisms of the core active ingredients of AS and discussed the translational value of colon-targeted delivery systems,providing effective evidence for clinical precision medication.关键词
当归/当归有效成分/溃疡性结肠炎/作用机制/结肠靶向递送系统Key words
Angelicae Sinensis Radix/active ingredient of Angelicae Sinensis Radix/ulcerative colitis/action mechanism/colon-targeted delivery system引用本文复制引用
王妍,张永宣,秦玉洁,符金玉,岳诗棋,修明慧,和建政..当归有效成分治疗溃疡性结肠炎的研究进展[J].中国中药杂志,2026,51(9):2428-2437,10.基金项目
国家自然科学基金项目(82360896) （82360896）
甘肃省高校产业支撑计划项目(2026CYZC-055) （2026CYZC-055）
甘肃研究生创新创业基金项目(2025CXZX-954) （2025CXZX-954）
