中国药理学与毒理学杂志2026，Vol.40Issue(5)：373-381,9.DOI:10.3867/j.issn.1000-3002.2026.08805
SIRT1/PGC-1α信号通路在糖尿病心肌病发生发展中的作用研究进展
Roles of SIRT1/PGC-1α signaling pathway in development and progression of diabetic cardiomyopathy:a review
摘要
Abstract
Diabetic cardiomyopathy(DCM)is a diabetes-specific cardiac complication character-ized by myocardial metabolic dysfunction and progressive cardiac dysfunction.Recent studies have found that the signaling pathway formed by silent information regulator 1(SIRT1)and peroxisome proliferator-activated receptor γ coactivator 1 α(PGC-1α)plays a pivotal role in the pathogenesis of DCM.This review examines the molecular architecture of the SIRT1/PGC-1α signaling pathway in general and its involvement in DCM progression by regulating mitochondrial quality control,oxidative stress balance,and energy metabolism reprogramming in particular.This article also evaluates natural bioac-tive compounds,chemically synthesized drugs,gene therapies,and other intervention strategies targeting this pathway in the hope of providing a new line of thought and potential therapeutic targets for DCM prevention and treatment.关键词
沉默信息调节因子1/过氧化物酶体增殖物激活受体γ辅激活因子1α/糖尿病心肌病/线粒体功能/能量代谢/氧化应激Key words
SIRT1/PGC-1α/diabetic cardiomyopathy/mitochondrial function/energy metabolism/oxidative stress分类
医药卫生引用本文复制引用
吴冬梅,谢小海,徐小惠..SIRT1/PGC-1α信号通路在糖尿病心肌病发生发展中的作用研究进展[J].中国药理学与毒理学杂志,2026,40(5):373-381,9.基金项目
广西自然科学基金(2023GXNSFAA026205) （2023GXNSFAA026205）
广西自然科学基金(2023GXNSFAA026214) Guangxi Natural Science Foundation of China Funded Project(2023GXNSFAA026205) （2023GXNSFAA026214）
and Guangxi Natural Science Foundation of China Funded Project(2023GXNSFAA026214) （2023GXNSFAA026214）
