中国实用妇科与产科杂志2026，Vol.42Issue(5)：498-505,8.DOI:10.19538/j.fk2026050105
基于分子分型的子宫内膜癌风险分层与辅助治疗决策优化
Optimization of risk stratification and adjuvant treatment decisions in endometrial cancer based on molecular classification
摘要
Abstract
Endometrial cancer comprises a high heterogeneous group of neoplasms with incidence rates rising year by year.Surgical removal of the tumor remains the mainstay of initial therapy for patients with indications,but based on more precise understanding of the molecular subtypes of endometrial cancer by the Cancer Genome Atlas(TCGA)classification,adjuvant treatment decisions have developed into a new mode of being directed by molecular characteristics.Molecular classification should be done for all types of endometrial cancer and follow the stepwise detection process of"POLE mutation-MMR status-p53 status",which is precisely categorized into four distinct molecular subtypes:POLE-mutated(POLEmut),mismatch repair deficient(MMRd),p53-abnormal(p53abn)and no specific molecular profile(NSMP).Based on the molecular classification,the risk stratification of prognosis is made and adjuvant treatment strategies are developed to achieve treatment precision and improve the treatment effects and patients' quality of life.关键词
子宫内膜癌/分子分型/风险分层/辅助治疗Key words
endometrial cancer/molecular classification/risk stratification/adjuvant treatment分类
医药卫生引用本文复制引用
冯莉苹,张师前..基于分子分型的子宫内膜癌风险分层与辅助治疗决策优化[J].中国实用妇科与产科杂志,2026,42(5):498-505,8.基金项目
中国医药教育协会2022重大科学攻关问题和医药技术难题课题项目(2022KTM024) The research projects of 2022 major scien-tific problems and medical technology problems of China Medical Education Association(2022KTM024) （2022KTM024）
