中医药信息2026，Vol.43Issue(6)：83-90,8.DOI:10.19656/j.cnki.1002-2406.20260613
胃癌前病变中有氧糖酵解的作用机制及中医药干预研究进展
Research Progress on the Mechanism of Aerobic Glycolysis in Gastric Precancerous Lesions and Intervention with Traditional Chinese Medicine
摘要
Abstract
Gastric precancerous lesions are a key reversible stage in gastric carcinogenesis,and their progression is closely associated with the aberrant activation of aerobic glycolysis.Aerobic glycolysis drives the generation of lactic acid and the formation of an acidic microenvironment by regulating key metabolic enzymes and upstream signaling pathways,thereby promoting the progression of gastric precancerous lesions.Traditional Chinese medicine(TCM),with its advantages of"holistic regulation and multi-target intervention",has shown great potential in regulating aerobic glycolysis and reversing gastric precancerous lesions.This study systematically reviews the molecular mechanisms of aerobic glycolysis in gastric precancerous lesions and the progress of TCM intervention.It is found that TCM monomers and compound formulas can synergistically regulate multiple aspects of the process.They can effectively inhibit the accumulation of lactic acid and the formation of an acidic microenvironment by multi-target regulation of key glycolytic enzymes(such as glucose transporter 1,hexokinase 2,pyruvate kinase M2,and lactate dehydrogenase A)and upstream signaling pathways[such as hypoxia-inducible factor-1α and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)],thereby reversing the lesion process.Their mechanisms of action are consistent with the pathogenesis of"spleen deficiency,blood stasis,and toxic damage"in TCM,demonstrating the scientific combination of traditional syndrome-based treatment and modern metabolic regulation mechanisms.关键词
胃癌前病变/有氧糖酵解/瓦博格效应/中医药Key words
Gastric precancerous lesions/Aerobic glycolysis/Warburg effect/Traditional Chinese medicine引用本文复制引用
张茜,王俊莹,葛惠男,沈贤敏,龚诚,刘敏..胃癌前病变中有氧糖酵解的作用机制及中医药干预研究进展[J].中医药信息,2026,43(6):83-90,8.基金项目
国家自然科学基金项目(82274423) （82274423）
江苏省名老中医药传承工作室建设项目(苏中医科教[2019]10 号) （苏中医科教[2019]10 号）
苏州市科技发展计划项目(SYSD2019243) （SYSD2019243）
