安徽医科大学学报2026，Vol.61Issue(5)：955-960,6.DOI:10.19405/j.cnki.issn1000-1492.2026.05.022
类风湿关节炎中巨噬细胞相关微小核糖核酸的研究进展
Research progress of macrophage-related microRNA in rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic synovial inflammation and joint destruction,with a complex pathogenesis.Macrophage polarization plays a pivotal role in disease progres-sion.Recent studies demonstrate that microRNA(miRNA),as critical post-transcriptional regulators,can partici-pate in the inflammatory response process by regulating the polarization state of macrophages,thereby aggravating RA joint damage.This review summarizes the mechanism of action of various miRNA in regulating macrophage po-larization,and emphasizes their potential therapeutic value in RA.关键词
类风湿关节炎/微小核糖核酸/巨噬细胞极化/炎症反应/信号通路Key words
rheumatoid arthritis/microRNA/macrophage polarization/inflammatory response/signaling pathways分类
医药卫生引用本文复制引用
蒋其江,罗成根,陈艳娟,田梅,陈永..类风湿关节炎中巨噬细胞相关微小核糖核酸的研究进展[J].安徽医科大学学报,2026,61(5):955-960,6.基金项目
国家自然科学基金项目(编号:82460325) National Natural Science Foundation of China(No.82460325) （编号:82460325）
