巴楚医学2026，Vol.9Issue(2)：10-15,6.DOI:10.3969/j.issn.2096-6113.2026.02.002
静脉-动脉血二氧化碳分压差
Venous-to-Arterial Carbon Dioxide Partial Pressure Difference
摘要
Abstract
Mixed venous oxygen saturation(SvO2)and central venous oxygen saturation(ScvO2)are commonly used to guide shock resuscitation.However,ScvO2 monitoring alone has not been shown to improve outcomes in patients with sepsis.The venous-to-arterial carbon dioxide partial pressure difference(ΔPCO2)has been proposed as an important indicator for evaluating the adequacy of resuscitation.Under physiological conditions,ΔPCO2 typically ranges from 5 to 7 mmHg.An increase in ΔPCO2 indicates a relatively insufficient cardiac output,which can be used to guide fluid resuscitation and titration of inotropic agents,thereby helping to assess the hemodynamic response to therapy.Nevertheless,ΔPCO2 has limitations:its sensitivity decreases under hyperdynamic circulatory states;in inflammatory conditions such as sepsis,microcirculatory dysfunction can complicate the relationship between ΔPCO2 and cardiac output;a normal ΔPCO2 does not exclude regional hypoperfusion;measurement errors may occur due to technical variability.When interpreted in conjunction with other hemodynamic and metabolic parameters,ΔPCO2 enables bedside and dynamic assessment of the balance between cardiac output and metabolic demand,thereby supporting more precise,individualized resuscitation strategies.关键词
休克/静脉-动脉血二氧化碳分压差/组织灌注/心输出量/氧代谢Key words
shock/venous-to-arterial carbon dioxide partial pressure difference(ΔPCO2)/tissue perfusion/cardiac output/oxygen metabolism分类
医药卫生引用本文复制引用
张彩虹,魏小艳,朱元州..静脉-动脉血二氧化碳分压差[J].巴楚医学,2026,9(2):10-15,6.基金项目
华中科技大学同济医学院护理学院2024年度自主创新基金项目(ZZCX2024L001) （ZZCX2024L001）
