北京中医药大学学报2026，Vol.49Issue(6)：741-747,7.DOI:10.3969/j.issn.1006-2157.2026.06.001
从共通病机论治慢性肾脏病
Treating chronic kidney disease based on the common pathogenesis
摘要
Abstract
Based on the theory of treatment based on pathomechanism differentiation,this article proposes a diagnostic and therapeutic strategy for chronic kidney disease(CKD)from the perspective of common pathogenesis,in light of the pathological characteristics of its occurrence,progression,and outcome.It systematically demonstrates that renal collateral concretions and masses represent a common pathogenic mechanism throughout the evolution of different primary CKD entities.Its formation and progression follow a vicious cycle characterized by collateral damage leading to concretions and masses formation,and accumulated concretions and masses further damaging the collaterals,which continuously aggravates injury to the kidney collaterals during chronic disease,thereby driving persistent renal function decline and disease progression.On this basis,this article identifies dissolving concretions and dispersing masses as the core therapeutic principle for CKD,and further constructs a diagnostic and therapeutic approach integrating stage-based treatment with disease-specific treatment.Along the longitudinal course of disease progression,CKD is divided into early,middle,and late stages according to the dynamic pathomechanism evolution,which are treated respectively by unblocking collaterals and resolving concretions,activating blood and resolving concretions,and reinforcing healthy qi and resolving concretions.According to the pathological features of different primary kidney diseases,specific therapeutic method are proposed across the horizontal dimension of disease categories,including clearing heat and replenishing qi to dissolve concretions,activating blood and unblocking collaterals to dissolve concretions,and dispelling wind and eliminating dampness to dissolve concretions.This framework contributes to a holistic understanding of the complex evolution of CKD pathomechanisms and provides a systematic traditional Chinese medicine theoretical basis and practical clinical pathway for delaying disease progression and improving patient prognosis.关键词
慢性肾脏病/辨机论治/共通病机/肾络癥瘕/消癥散结Key words
chronic kidney disease/treatment on pathomechanism differentiation/common pathogenesis/renal collateral concretions and masses/dissolving concretions and dispersing masses分类
医药卫生引用本文复制引用
姜伟民,王耀献,孙卫卫,魏蜀吴,杨杰,杨康,刘杨,孙立巧,李鑫荣..从共通病机论治慢性肾脏病[J].北京中医药大学学报,2026,49(6):741-747,7.基金项目
国家重点研发计划项目(No.2025YFC3509800) （No.2025YFC3509800）
国家自然科学基金项目(No.82174356) （No.82174356）
第六批全国中医临床优秀人才研修项目(国中医药人教函[2025]256 号) （国中医药人教函[2025]256 号）
北京中医药大学"岐黄英才·名医培育计划"项目(No.Y2023B08) National Key R&D Program of China(No.2025YFC3509800) （No.Y2023B08）
