滨州医学院学报2026，Vol.49Issue(3)：284-287,4.DOI:10.19739/j.cnki.issn1001-9510.2026.03.011
基于两样本孟德尔随机化探究干果摄入与2型糖尿病的因果关系
Exploration of the causal association between nut intake and type 2 diabetes mellitus with two-sample Mendelian randomization
王平平 1李瑾1
作者信息
- 1. 天津医科大学朱宪彝纪念医院神经内科 天津 300134||天津市内分泌研究所 天津 300134||国家卫生健康委员会激素与发育重点实验室 天津 300134||天津市代谢性疾病重点实验室 天津 300134
- 折叠
摘要
Abstract
Objective To explore the causal association between nut intake and the risk of type 2 diabetes mellitus with two-sample Mendelian randomization(MR).Methods Genome-wide association study(GWAS)-based pooled data were used to perform two-sample Mendelian randomization with nut intake as the exposure and type 2 diabetes mellitus as the outcome.The primary analysis method was inverse variance weighting(IVW).F-value statistics and Cochran's Q statistics were used to test the stability and heterogeneity of instrumental variables.MR-Egger regression,weighted median method,simple plurality-based estimation,weighted plurality-based estimation,and leave-one-out method were used for sensitivity analyses.Results A total of 41 single-nucleotide polymorphism loci were included as instrumental variables for nut intake.The results of Mendelian randomi-zation indicated an inverse causal association between nut intake and type 2 diabetes mellitus(IVW method OR:0.48,95％confidence interval:0.30-0.76,P=0.002),and there was no pleiotropy.The results obtained from the weighted median and leave-one-out methods were consistent with IVW.Conclusion There is a negative causal relationship between nut intake and the onset of type 2 diabetes mellitus.关键词
干果摄入/2型糖尿病/孟德尔随机化/全基因组关联分析/因果关联Key words
nut intake/type 2 diabetes mellitus/Mendelian randomization/genome-wide association analysis/causal associ-ation分类
医药卫生引用本文复制引用
王平平,李瑾..基于两样本孟德尔随机化探究干果摄入与2型糖尿病的因果关系[J].滨州医学院学报,2026,49(3):284-287,4.
