重庆医学2026，Vol.55Issue(6)：1201-1207,7.DOI:10.3969/j.issn.1671-8348.2026.06.001
早产儿胰岛素抵抗的影响因素分析
Analysis of influencing factors of insulin resistance in premature infants
摘要
Abstract
Objective To analyze the influencing factors of insulin resistance(IR)in premature infants with gestational age less than 32 weeks.Methods A total of 111 premature infants admitted to the hospital from March 2022 to June 2024 were selected as the research subjects and divided into the IR group(n=53)and the non-IR group(n=58)based on whether IR occurred 14 days after birth.Baseline characteristics and clinical data of the mothers and premature infants were collected,and metabolic and oxidative stress indicators were measured.Stepwise logistic regression analysis was used to explore the influencing factors of IR occur-rence in premature infants.Results Compared with the non-IR group,the incidence of neonatal hyperglycemia in the IR group was higher(18.9%vs.3.5%),and the duration of non-invasive nasal ventilation was longer[144.0(48.0,216.0)h vs.89.5(0,156.5)h].The levels of insulin[14.44(12.92,16.77)mU/L vs.11.67(10.59,12.89)mU/L],adiponectin[1 860.20(1 315.82,2 091.36)pg/mL vs.1 540.61(1 320.48,1 803.21)pg/mL],leptin[3.06(2.68,3.80)μg/mL vs.2.68(2.38,3.15)μg/mL],blood glucose[5.00(4.38,5.61)mmol/L vs.3.71(3.40,4.24)mmol/L],superoxide dismutase[SOD,26.75(12.90,45.71)U/mL vs.17.51(9.20,36.73)U/mL],malondialdehyde[MDA,0.96(0.66,1.11)nmol/mL vs.0.60(0.46,0.83)nmol/mL],and advanced oxidation protein products[AOPP,39.84(35.76,49.80)μmol/L vs.36.85(31.02,41.74)μmol/L]were higher,and the differences were statistically significant(P<0.05).The results of multivariate logis-tic regression analysis showed that neonatal hyperglycemia(OR=8.04,95%CI:1.51-42.05),MDA(OR=4.07,95%CI:1.19-16.04),and AOPP(OR=1.09,95%CI:1.03-1.16)were the influencing factors for IR(P<0.05).Conclusion Oxidative stress may be involved in the occurrence of IR in premature infants.关键词
早产儿/胰岛素抵抗/影响因素/代谢/氧化应激Key words
premature infants/insulin resistance/influencing factors/metabolism/oxidative stress分类
医药卫生引用本文复制引用
何建平,王永明,汪珍,丁丽,刘芙君,马剑..早产儿胰岛素抵抗的影响因素分析[J].重庆医学,2026,55(6):1201-1207,7.基金项目
宁夏自然科学基金项目(2025AAC031041) （2025AAC031041）
宁夏医科大学校级基金项目(XM2023215). （XM2023215）
