东华大学学报（英文版）2026，Vol.43Issue(3)：23-31,9.DOI:10.19884/j.1672-5220.202510011
具有可注射性及抗菌性能的动态交联水凝胶
A Dynamically Crosslinked Hydrogel with Injectable and Antibacterial Properties
摘要
Abstract
The clinical management of chronic wounds is frequently challenged by bacterial infection and biofilm formation.To address this,we developed an injectable hydrogel,denoted as AMCS@ODex,via dynamic Schiff base bonding between amide-modified chitosan(AMCS)and oxidized dextran(ODex).This crosslinking strategy not only mitigated the inherent limitations of chitosan,such as poor solubility and mechanical properties,but also endowed the hydrogel with excellent shear-thinning behaviors.AMCS@ODex exhibited antibacterial efficacy against Escherichia coli(E.coli)and methicillin-resistant Staphylococcus aureus(MRSA),and the antibacterial rates against E.coli and MRSA were 58%and 73%,respectively.Furthermore,it effectively disrupted pre-formed MRSA biofilms,leading to a disruption rate approximately 50%.Critically,the hydrogel exhibited outstanding biocompatibility,supporting over 90%viability of L929 fibroblast cells.By integrating good antibacterial performance,with desirable mechanical properties and high biocompatibility,the AMCS@ODex hydrogel presents potential biomedical applications,particularly in the fight against bacterial infections.关键词
水凝胶/席夫碱/抗菌活性/壳聚糖Key words
hydrogel/Schiff base/antibacterial activity/chitosan分类
医药卫生引用本文复制引用
王月月,伍思琴,罗金兰,王义..具有可注射性及抗菌性能的动态交联水凝胶[J].东华大学学报（英文版）,2026,43(3):23-31,9.基金项目
National Natural Science Foundation of China(No.81861138040) （No.81861138040）
Natural Science Foundation of Shanghai City of China(No.20ZR1401800) （No.20ZR1401800）
