东华大学学报（英文版）2026，Vol.43Issue(3)：32-43,12.DOI:10.19884/j.1672-5220.202510006
纳米纤维/两性离子水凝胶复合材料用于抗异物反应
Nanofiber/Zwitterionic Hydrogel Composite for Anti-Foreign Body Reaction
摘要
Abstract
In this study,we developed a nanofiber/zwitterionic hydrogel composite aimed at overcoming the in vivo foreign body reaction.This composite leverages the adhesive properties of polydopamine(PDA)to integrate trimethylamine N-oxide(TMAO)zwitterionic hydrogel with a three-dimensional poly(lactic acid)(PLA)nanofiber membrane.The resulting material exhibits the robust mechanical properties characteristic of PLA,featuring a tensile strength of approximately 13 MPa and an elongation at break exceeding 20%.Furthermore,owing to the TMAO zwitterionic hydrogel,the composite demonstrates exceptional resistance to biological contamination.After 30 d in a murine model,the composite does not develop a dense collagen layer on its surface,maintaining a thickness of less than 30 μm.关键词
纳米纤维/水凝胶/抗异物反应/两性离子Key words
nanofiber/hydrogel/anti-foreign body reaction/zwitterion分类
医药卫生引用本文复制引用
党向宇,高玉洁,陈支泽..纳米纤维/两性离子水凝胶复合材料用于抗异物反应[J].东华大学学报（英文版）,2026,43(3):32-43,12.基金项目
Fundamental Research Funds for the Central Universities,China(No.2232025A-09) （No.2232025A-09）
