东华大学学报（英文版）2026，Vol.43Issue(3)：64-75,12.DOI:10.19884/j.1672-5220.202509009
可生物降解聚合物支架的进展:综述
Advances in Biodegradable Polymeric Stents:A Review
摘要
Abstract
Cardiovascular diseases(CVDs)are the leading cause of global mortality,and impose a significant burden on healthcare systems worldwide.Traditional treatments,such as metallic stents,often lead to long-term complications,including restenosis,thrombosis,and chronic inflammation,due to permanent implantation.In response,biodegradable polymeric stents(BPSs)have emerged as a groundbreaking solution,offering temporary mechanical support to diseased vessels while degrading harmlessly over time,thereby promoting natural vascular healing and regeneration.This review synthesizes recent advancements in the development of BPSs,focusing on innovative biodegradable polymers(e.g.,poly(lactic acid)(PLA),poly(lactic-co-glycolic acid)(PLGA),and polycaprolactone(PCL)),and advanced manufacturing methods(e.g.,three-dimensional printing and laser cutting).While preclinical and clinical studies demonstrate promising outcomes,challenges persist in balancing mechanical durability with controlled degradation rates,managing inflammatory responses to acidic byproducts,and ensuring long-term safety.Future directions emphasize smart materials,hybrid manufacturing strategies,and personalized designs enabled by artificial intelligence.By addressing these challenges,BPSs hold transformative potential to redefine cardiovascular interventions,ultimately improving patient outcomes and reducing the global burden of CVDs.关键词
可生物降解聚合物支架/心血管疾病/注塑成型/激光切割/编织/3D打印/4D打印Key words
biodegradable polymeric stent/cardiovascular disease/injection molding/laser cutting/weaving/3D printing/4D printing分类
医药卫生引用本文复制引用
魏永忠,蔡广芳,宋佳慧,秦承雪,莫秀梅..可生物降解聚合物支架的进展:综述[J].东华大学学报（英文版）,2026,43(3):64-75,12.基金项目
Shanghai Science and Technology Innovation Plan,China(No.20DZ2254900) （No.20DZ2254900）
Sino-German Science Foundation Research Exchange Center,China(No.M-0263) （No.M-0263）
