中国耳鼻咽喉头颈外科2026，Vol.33Issue(4)：181-185,5.DOI:10.16066/j.1672-7002.2026.04.001
长链非编码RNA MIR31HG在喉鳞状细胞癌中的表达及其与预后不良的关系
The expression of lncRNA MIR31HG in laryngeal squamous cell carcinoma and its relationship with poor prognosis
摘要
Abstract
OBJECTIVE To investigate the expression of long noncoding RNA MIR31HG(lncRNA MIR31HG)in laryngeal squamous cell carcinoma(LSCC)tissues and its relationship with poor prognosis.METHODS A total of 113 LSCC patients admitted to the 980th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army from January 2022 to December 2024 were selected.Tumor tissues and adjacent normal tissues were collected during surgical resection,and the expression level of lncRNA MIR31HG was detected by quantitative real-time PCR(qPCR).According to the optimal cut-off value of lncRNA MIR31HG for diagnosing LSCC,LSCC patients were divided into the high expression group(lncRNA MIR31HG≥1.61)and the low expression group(lncRNA MIR31HG<1.61).Compare the differences in the expression of different lncRNA MIR31HG and the clinicopathological characteristics of patients with LSCC.Postoperative follow-up was conducted to record the overall survival(OS)and progression-free survival(PFS)of LSCC patients,and Kaplan-Meier curves were generated to illustrate survival outcomes.Univariate and multivariate Cox regression analyses were performed to identify independent risk factors associated with poor prognosis in LSCC patients.RESULTS The expression level of lncRNA MIR31HG in LSCC tissues(2.17±0.58 vs.0.81±0.16)was significantly higher than that in adjacent tissues(t=16.573,P<0.001).The ROC curve showed that the optimal cut-off value of lncRNA MIR31HG for diagnosing LSCC was 1.61,and the AUC was 0.894(95%CI=0.837-0.928).The incidences of stage Ⅲ-Ⅳ(90.0%vs.10.0%),T3-T4(87.8%vs.12.2%),N2-N3(96.9%vs.3.1%),M1(94.4%vs.5.6%),poor differentiation(92.3%vs.7.7%),and lymph node metastasis(90.5%vs.9.5%)were significantly higher in the lncRNA MIR31HG high-expression group than in the low-expression group(all P<0.05).Kaplan-Meier survival analysis revealed that the high-expression group exhibited significantly lower OS(70.84%vs.90.15%)and PFS(52.36%vs.74.18%)compared with the low-expression group(P<0.05).Univariate and multivariate Cox regression analyses indicated that stage III-IV disease,T3-T4 stage,N2-N3 stage,M1 stage,poor differentiation,lymph node metastasis and high expression of lncRNA MIR31HG were risk factors for poor prognosis in LSCC patients(P<0.05).CONCLUSION lncRNA MIR31HG is highly expressed in LSCC tissues,and its elevated expression is closely correlated with advanced tumor stage,poor differentiation,and lymph node metastasis,serving as an independent risk factor for unfavorable prognosis in LSCC patients.关键词
喉肿瘤/癌,鳞状细胞癌/预后长链非编码RNA MIR31HG/临床病理Key words
Laryngeal Neoplasms/Carcinoma,Squamous Cell/Prognosis/lncRNA MIR31HG/clinical pathology引用本文复制引用
孔延男,刘亮,牛云峰,赵惠玲..长链非编码RNA MIR31HG在喉鳞状细胞癌中的表达及其与预后不良的关系[J].中国耳鼻咽喉头颈外科,2026,33(4):181-185,5.基金项目
河北省医学科学研究课题(20240854) （20240854）
