分析化学2026，Vol.54Issue(6)：1034-1042,9.DOI:10.19756/j.issn.0253-3820.251223
多孔调控的FeNC纳米酶用于四环素的比色检测
Porous-Engineered FeNC Nanozyme for Colorimetric Detection of Tetracycline
摘要
Abstract
A colorimetric detection strategy for tetracycline(TC)based on a mesopore-modulated single-atom iron nanozyme is proposed.Compared to the unmodulated FeNC,the modulated nanozyme(FeNC-meso)features a concave porous nanostructure,which significantly promotes the exposure of active sites.Concurrently,FeNC-meso possesses more defects,which trigger partial charge transfer and facilitate the generation of reactive oxygen species(ROS),thereby markedly enhancing catalytic efficiency.Experimental results demonstrate that the specific activity(SA)and maximum reaction rate(vmax)of the FeNC-meso nanozyme are increased by factors of 2.01 and 2.06,respectively,compared to conventional FeNC.Leveraging its oxidase-like activity,a colorimetric detection system for TC is constructed.This system exhibits a linear detection range of 1.0 to 87.5 μmol/L and a limit of detection(LOD,S/N=3)of 0.23 μmol/L,demonstrating its effective capability for TC detection.The colorimetric detection platform exhibits excellent selectivity,anti-interference ability,and robust reliability in real sample analysis.The TC contents in real river and lake water samples are analyzed by this method,which are compared with those obtained by high-performance liquid chromatography(HPLC).The results from both methods are consistent.This study provides a promising research strategy for nanozyme structural regulation studies and antibiotic detection in the environment.关键词
单原子催化剂/铁基纳米酶/多孔调控/四环素/比色检测Key words
Single-atom catalyst/Iron-based nanozyme/Mesopore engineering/Tetracycline/Colorimetric detection引用本文复制引用
颜景浩,陈珺,李明旭,徐鹏,逯一中,姜媛媛..多孔调控的FeNC纳米酶用于四环素的比色检测[J].分析化学,2026,54(6):1034-1042,9.基金项目
国家自然科学基金项目(No.22172063)资助. Supported by the National Natural Science Foundation of China(No.22172063). （No.22172063）
