高等学校化学学报2026，Vol.47Issue(7)：157-165,9.DOI:10.7503/cjcu20250356
抗菌肽Magainin和Indolicidin对革兰氏阴性菌和阳性菌膜的作用机制
Mechanism of Action of Antimicrobial Peptides Magainin and Indolicidin on Gram-negative and Gram-positive Bacterial Membranes
摘要
Abstract
Molecular dynamics simulations were employed to comparatively investigate the interaction mechanisms of the antimicrobial peptides Magainin and Indolicidin with the cell membranes of Gram-negative and Gram-positive bacteria,respectively.Structural changes,adsorption process,membrane perturbations,and peptide-membrane interactions of both peptides were systematically analyzed.The results demonstrate that Magainin,which exhibits an unstable helical structure in an aqueous environment,forms a stable helix upon binding to membranes.Moreover,it shows stronger binding ability and more significant disruption on the membrane of Gram-negative bacteria,indicating its higher selectivity for this type of bacteria.In contrast,Indolicidin maintains a flexible random coil structure,enabling rapid adsorption and stable binding to the membrane surface primarily through synergistic electrostatic attraction and hydrophobic interactions.However,it causes relatively minor perturbation to both types of bacterial membranes.This comparative study provides a theoretical basis for understanding the selectivity of Magainin for Gram-negative bacteria and the broad-spectrum activity of Indolicidin.关键词
Magainin/Indolicidin/革兰氏阴性菌膜/革兰氏阳性菌膜Key words
Magainin/Indolicidin/Gram-negative bacterial membrane/Gram-positive bacterial membrane分类
化学化工引用本文复制引用
安彦楠,邵学广,蔡文生..抗菌肽Magainin和Indolicidin对革兰氏阴性菌和阳性菌膜的作用机制[J].高等学校化学学报,2026,47(7):157-165,9.基金项目
国家自然科学基金(批准号:22373051)资助. Supported by the National Natural Science Foundation of China(No.22373051). （批准号:22373051）
