神经损伤与功能重建2026，Vol.21Issue(6)：322-327,6.DOI:10.16780/j.cnki.sjssgncj.20260639
急性脉络膜前动脉区梗死临床特点分析及预测早期进展和预后的生物标志物
Analysis of Clinical Characteristics of Acute Anterior Choroidal Artery Infarction and Biomarkers for Predicting Early Progression and Prognosis
陈彬 1程旭 2韩燕飞 1赵莹莹 1孙金梅 1张拥波1
作者信息
- 1. 首都医科大学附属北京友谊医院 神经内科 北京 100050
- 2. 首都医科大学附属北京友谊医院 影像科 北京 100050
- 折叠
摘要
Abstract
Objective:To explore rapid predictive biomarkers for early progression and prognosis in acute anterior choroidal artery(AChA)infarction.Methods:A retrospective analysis was conducted on the clinical data of 104 patients with acute AChA infarction.The laboratory indicators,National Institutes of Health Stroke Scale(NIHSS)scores,modified Rankin Scale(mRS)scores,clinical manifestations,and treatment responses were compared between the early progression and non-progression groups,as well as between the good prognosis and poor prognosis groups.Results:The neutrophil-to-lymphocyte ratio(NLR)in the early progression group was higher than that in the non-progression group(P=0.047).The NIHSS scores at admission and discharge,and the mRS scores at discharge in the progression group were significantly higher than those in the non-progression group(all P＜0.001).The C-reactive protein(CRP)level in the poor prognosis group was higher than that in the good prognosis group(P=0.034).Patients presenting with hemiplegia as the main manifestation were significantly more prevalent in the progression and poor prognosis groups(P=0.022,0.021).Ten patients(9.6％)received rt-PA thrombolysis;no bleeding complications occurred,and symptoms improved in all cases.In the progression group,there were no significant differences in discharge NIHSS and mRS scores between the patients treated with argatroban(n=9)and those untreated(n=10)(P=0.431,0.200),and no bleeding events occurred in either group.Conclusion:NLR may be a potential biomarker for predicting early progression in patients with acute AChA infarction without ipsilateral large vessel disease;CRP may serve as a marker for predicting the short-term prognosis of these patients;early neurological deterioration is an important predictor of short-term prognosis in AChA infarction patients.rt-PA thrombolytic therapy is safe and effective,while argatroban treatment did not significantly improve the short-term prognosis of patients in the progression group.关键词
脉络膜前动脉/脑梗死/早期进展/中性粒细胞与淋巴细胞比值/预后/C反应蛋白Key words
anterior choroidal artery/cerebral infarction/early progression/neutrophil-to-lymphocyte ratio/prognosis/C-reactive protein分类
医药卫生引用本文复制引用
陈彬,程旭,韩燕飞,赵莹莹,孙金梅,张拥波..急性脉络膜前动脉区梗死临床特点分析及预测早期进展和预后的生物标志物[J].神经损伤与功能重建,2026,21(6):322-327,6.
