广西医科大学学报2026，Vol.43Issue(3)：303-313,11.DOI:10.16190/j.cnki.45-1211/r.2026.03.001
聚集诱导发光活性天然产物及其衍生物的生物医学应用
Biomedical applications of AIE-active natural products and derivatives
摘要
Abstract
Natural products,endowed by nature,are renowned for their structural diversity and favorable bio-compatibility.However,their application in bioimaging still faces challenges such as low sensitivity,poor visua-lization capability,inadequate real-time monitoring performance,and compromised biocompatibility.Further-more,in therapeutic applications,real-time imaging and dynamic monitoring remain plagued by high background noise and low sensitivity.Fortunately,the discovery of aggregation-induced emission(AIE)provides a novel per-spective for addressing these limitations.In recent years,researchers have identified numerous natural products that either inherently exhibit AIE characteristics or can be judiciously engineered into efficient AIE luminogens(AIEgens).These natural AIEgens function as illuminated"colorful"fluorescent probes,not only providing a unique window for elucidating traditional pharmacological mechanisms but also demonstrating great potential in integrated diagnostics and therapeutics across various biomedical fields,including organelle imaging,cancer the-ranostics,and antibacterial/anti-inflammatory applications.This review systematically summarizes the recent ad-vances of AIE-active natural products,aiming to provide a"navigation map"for natural AIE research.关键词
聚集诱导发光/AIE发光基元/天然产物/天然产物衍生物/生物医学应用/生物成像/细胞器成像/癌症诊疗/诊疗一体化Key words
aggregation-induced emission/AIEgens/natural products/natural product derivatives/biomedical application/bioimaging/organelle imaging/cancer theranostics/theranostics分类
医药卫生引用本文复制引用
刘丹,杜学柯,宁峙彭,张天富,唐本忠..聚集诱导发光活性天然产物及其衍生物的生物医学应用[J].广西医科大学学报,2026,43(3):303-313,11.基金项目
国家自然科学基金重大项目(22595401) （22595401）
广东省基础与应用基础研究基金资助项目(2024A1515010855) （2024A1515010855）
广西青年人才托举工程项目(GXYESS2025006) （GXYESS2025006）
