广西医科大学学报2026，Vol.43Issue(3)：382-390,9.DOI:10.16190/j.cnki.45-1211/r.2026.03.008
基于孟德尔随机化和人群横断面研究探索糖尿病与泌尿系统肿瘤的相关性
Association of diabetes mellitus with urinary tract tumors:evidence from Mendelian random-ization and population-based cross-sectional study
摘要
Abstract
Objective:To investigate the impact of diabetes mellitus(DM)on the risk of developing urinary tract tumors.Methods:Two-sample Mendelian randomization(MR)analyses were conducted using summary statis-tics from the IEU OpenGWAS and FinnGen databases.Phenotypic validation was conducted using cross-sectional population analysis,and secondary MR analysis was performed to enhance the strength of evidence.Results:Preliminary MR analysis revealed a weak association between type 2 diabetes mellitus(T2DM)and bladder cancer(OR=1.001,95%CI:1.000-1.001,P=0.010).DM(OR=1.016,95%CI:1.001-1.032,P=0.037)and T2DM(OR=1.002,95%CI:1.001-1.002,P=0.021)were confirmed as risk factors for prostate cancer(PCa),with the findings supported by secondary MR,and were validated by cross-sectional analysis.Subgroup analysis showed that T2DM increased the risk of PCa in situ(OR=2.114,95%CI:1.062-4.240,P=0.032).Conclusion:T2DM increases the risk of PCa,especially for carcinoma in situ.关键词
孟德尔随机化/糖尿病/泌尿系统/肿瘤/前列腺癌/膀胱癌/肾癌/横断面研究Key words
Mendelian randomization/diabetes mellitus/urinary system/tumor/prostate cancer/bladder cancer/kidney cancer/cross-sectional study分类
医药卫生引用本文复制引用
谢碁基,龙新阳,梁俭,梁坤华,刘净闻,麦迪曼,马正航,廖金玲,陈阳..基于孟德尔随机化和人群横断面研究探索糖尿病与泌尿系统肿瘤的相关性[J].广西医科大学学报,2026,43(3):382-390,9.基金项目
广西自然科学基金资助项目(2022JJB140197) （2022JJB140197）
国家自然科学基金资助项目(82460596) （82460596）
