广西医科大学学报2026，Vol.43Issue(3)：443-453,11.DOI:10.16190/j.cnki.45-1211/r.2026.03.014
气道上皮—间充质转化在哮喘气道重塑中的作用研究进展
Research progress on the role of airway epithelial-mesenchymal transition in airway remode-ling in asthma
摘要
Abstract
Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation,reversible airflow limitation and airway remodeling.Airway remodeling is the key pathological basis for the progression of mild asthma to severe and refractory asthma.As an early core event and primary feature of airway remodeling,epithelial-mesenchymal transition(EMT)is initiated by direct damage to the airway epithelial barrier caused by harmful stimuli such as allergens,PM2.5 and tobacco smoke.It is coordinately regulated by inflammatory factors including TGF-β,the interleukin family,TNF-α and signaling pathways such as PI3K/AKT,Smad and Wnt/β-catenin,accompanied by downregulated expression of E-cadherin and elevated levels of mesenchymal markers including α-SMA and vimentin.Non-coding RNAs(miRNA,lncRNA)and key genes such as PER2 and GLCCI1 participate in the fine regulation of EMT at the transcriptional and epigenetic levels.At present,biologics,macro-lides,hormones,signaling pathway inhibitors and traditional Chinese medicine have shown potential in inhibiting EMT and improving airway remodeling.However,clinical translation still faces challenges including disturbance of physiological functions,phenotypic heterogeneity,unclear long-term safety and insufficient large-sample clini-cal evidence.Further elucidation of the regulatory network of EMT in asthma airway remodeling and exploration of precise,reversible and safe targeted intervention strategies are of great theoretical value and clinical signifi-cance for reversing airway remodeling and ameliorating the prognosis of severe and refractory asthma.关键词
支气管哮喘/上皮细胞/上皮—间充质转化/气道上皮屏障/气道重塑/信号通路/难治性哮喘/非编码RNAsKey words
bronchial asthma/epithelial cells/epithelial-mesenchymal transition/airway epithelial barrier/air-way remodeling/signaling pathways/refractory asthma/non-coding RNAs分类
医药卫生引用本文复制引用
徐丽平,邓静敏..气道上皮—间充质转化在哮喘气道重塑中的作用研究进展[J].广西医科大学学报,2026,43(3):443-453,11.基金项目
广西自然科学基金资助项目(2025GXNSFAA069766) （2025GXNSFAA069766）
