肝脏研究（英文）2026，Vol.10Issue(2)：177-188,12.DOI:10.1016/j.livres.2026.05.003
PPARα activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosis
PPARα activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosis
Hang-Fei Liang 1Hui-Chang Bi 2Chuo-Ying Mai 3Xuan Li 3Jia-Ning Tian 4Hai-Guo Su 4Min Huang 4Jian-Hong Fang 3Hai-Tao Wang 3Xiao Yang5
作者信息
- 1. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,China
- 2. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,China||The State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Shenzhen Graduate School of Peking University,Shenzhen,Guangdong,China
- 3. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China
- 4. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,Guangdong,China
- 5. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,Guangdong,China||The State Key Laboratory of Chemical Oncogenomics,School of Chemical Biology and Biotechnology,Shenzhen Graduate School of Peking University,Shenzhen,Guangdong,China
- 折叠
摘要
关键词
Cholestatic liver injury(CLI)/Peroxisome proliferator-activated receptor alpha(PPARα)/Pyroptosis/NOD-like receptor protein 3(NLRP3)/Apoptosis protease-activating factor-1(APAF-1)Key words
Cholestatic liver injury(CLI)/Peroxisome proliferator-activated receptor alpha(PPARα)/Pyroptosis/NOD-like receptor protein 3(NLRP3)/Apoptosis protease-activating factor-1(APAF-1)引用本文复制引用
Hang-Fei Liang,Hui-Chang Bi,Chuo-Ying Mai,Xuan Li,Jia-Ning Tian,Hai-Guo Su,Min Huang,Jian-Hong Fang,Hai-Tao Wang,Xiao Yang..PPARα activation alleviates lithocholic acid-induced liver injury by inhibiting pyroptosis[J].肝脏研究（英文）,2026,10(2):177-188,12.基金项目
This work was supported by the National Key R&D Program of China(2022YFA1106700 and 2022YFA1104900),the National Natural Science Foundation of China(82274001,U23A20535,and 82204226),the Shenzhen Science and Technology Program(KQTD20190929174023858),the Guangdong Basic and Applied Basic Research Foundation(2024A1515011086),and the Natural Science Foundation of Sichuan Province(2024NSFSC0638). （2022YFA1106700 and 2022YFA1104900）
