海南师范大学学报（自然科学版）2026，Vol.39Issue(2)：163-168,6.DOI:10.12051/j.issn.1674-4942.2026.02.006
打箭菊萜类成分研究
Study on Terpenoid Constituents from Tanacetum tatsienense
摘要
Abstract
In this study,systematic solvent extraction techniques and different chromatographic methods,such as normal-phase and reverse-phase silica gel column chromatography,along with semi-preparative high-performance liquid chromatography,were employed to isolate and purify the chemical components extracted from the ethyl acetate extract of Tanacetum tatsienense.The structures of the obtained compounds were determined using a range of spectroscopic techniques,including 1D and 2D NMR,high-resolution mass spectrometry,quantum chemical calculations,and conventional chemical methods.Six terpenoids were isolated and identified.Among them,compound 1 was recognized as a new norcarotenoid glycoside,named as tatsienenoside A(1).The remaining compounds were identified as known terpenoids,including 3β-hydroxy-β-ionone(2),1β-hydroxy-7-epi-costic acid methyl ester(3),arnidiol(4),faradiol(5),and maniladiol(6).The anti-proliferative activity of the isolated terpenoids was assessed using the CCK-8 method.The results indicated that arnidiol(4)exhibited moderate anti-proliferative activity against human non-small cell lung cancer A549 cells,with an IC50 value of(12.58±0.60)μmol/L.关键词
打箭菊/萜类成分/去胡萝卜素苷/抗增殖活性Key words
Tanacetum tatsienense/terpenoid/norcarotenoid glycoside/anti-proliferative activity分类
医药卫生引用本文复制引用
陈帝君,杜艳,熊慧,杨光忠,陈玉..打箭菊萜类成分研究[J].海南师范大学学报（自然科学版）,2026,39(2):163-168,6.基金项目
国家重点研发计划项目(2022YFC3502200) （2022YFC3502200）
