海南师范大学学报（自然科学版）2026，Vol.39Issue(2)：177-183,7.DOI:10.12051/j.issn.1674-4942.2026.02.008
鸡嘴簕的化学成分及生物活性研究
Chemical Constituents and Bioactivity Studies of Caesalpinia sinensis Hemsl.
摘要
Abstract
To study the chemical constituents and biological activities of Caesalpinia sinensis Hemsl.,separation and purification of its leaf and stem compounds were performed using separation techniques such as silica gel column chromatography,Sephadex LH-20 gel column chromatography,and HPLC.The purified compounds were characterized employing spectroscopic techniques including NMR/MS.A total of 11 compounds were isolated and identified from the leaves and stems and elucidated as neocaesalpin D(1),neocaesalpin N(2),neocaesalpin L(3),caesalpin F(4),7-oxodehydroabietic acid(5),3-deoxysappanone B(6),bonducellin(7),(3R)-dihydrobonducellin(8),(E)-7-methoxy-3-(4′-methoxybenzylidene)chroman-4-one(9),(aR,7R)-13-O-acetyl-7-dehydroxyprotosappanin B(10),and(aS,7R)-13-O-acetyl-7-dehydroxyprotosappanin B(11).All compounds were first isolated from this plant.The antiproliferative activity of cassane-type diterpenes(1-4)against the human breast cancer cell line MDA-MB-468 was tested,and the results demonstrated that compounds 1-4 exhibited no significant activity against the human breast cancer tumor cell line.关键词
鸡嘴簕/化学成分/二萜/高异黄酮Key words
Caesalpinia sinensis Hemsl/chemical constituents/diterpenoids/homoisoflavonoids分类
医药卫生引用本文复制引用
李瑰萍,李海都,陈昌华,阳小雨,詹睿..鸡嘴簕的化学成分及生物活性研究[J].海南师范大学学报（自然科学版）,2026,39(2):177-183,7.基金项目
云南省教育厅科学研究基金教师类项目(2024J0137) （2024J0137）
