河北医学2026，Vol.32Issue(6)：984-990,7.DOI:10.3969/j.issn.1006-6233.2026.06.016
Th17/Treg及IL-6在不同分期胃癌表达水平及其对预后的影响
Expression Levels of Th17/Treg and IL-6 level in Gastric Cancer at Different Stages and Their Impact on Prognosis
摘要
Abstract
Objective:To investigate the expression levels of Th17/Treg and IL-6 level in gastric cancer(GC)at different stages and their impact on prognosis.Methods:A total of 110 patients with gastric cancer admitted to our hospital from January 2021 to January 2024 were enrolled and divided into Stage Ⅰ(n=42),Stage Ⅱ(n=28),Stage Ⅲ(n=26)and Stage Ⅳ(n=14)according to TNM staging.General clinical da-ta,the levels of Th17,Treg,Th17/Treg ratio and IL-6 were analyzed among all groups.Fasting venous blood(5 mL)was collected on the next day after enrollment,and Th17,Treg were detected by flow cytometry,with IL-6 level measured simultaneously.Pearson correlation analysis was used to evaluate the correlation between indicators and TNM staging.All patients were followed up for 1 year and further divided into a favorable prog-nosis group(n=84)and a poor prognosis group(n=26)based on prognostic outcomes.The levels of Th17,Treg,Th17/Treg ratio and IL-6 level were compared between the two prognostic groups,and receiver operat-ing characteristic(ROC)curve analysis was performed to assess the diagnostic value of these indicators for the prognosis of gastric cancer patients.Results:Compared with Stage Ⅰ,the tumor diameter in Stage Ⅱ was sig-nificantly increased(P<0.05),while no significant differences were observed in differentiation degree,infil-tration depth and lymph node metastasis(P>0.05).Compared with Stage Ⅱ,Stage Ⅲ had significantly lar-ger tumor diameter,higher proportion of poorly differentiated tumors,higher proportion of tumors with infiltra-tion depth below the mucosal layer and higher incidence of lymph node metastasis(P<0.05);no significant differences were observed in the above indicators between Stage Ⅳ and Stage Ⅲ(P>0.05).The levels of Th17,Treg,Th17/Treg ratio and IL-6 level increased significantly with the elevation of TNM staging,with statistically significant differences(P<0.05).TNM stage was positively correlated with the levels of Th17,Treg,Th17/Treg ratio and IL-6 level(r=0.902,0.738,0.813 and 0.654,respectively,all P<0.001).The 1-year survival rates were 92.86%for Stage Ⅰ,82.14%for Stage Ⅱ,65.38%for Stage Ⅲ and 35.71%for Stage Ⅳ patients,and decreased significantly with the progression of TNM stage(P<0.05).The lev-els of Th17,Treg,Th17/Treg ratio and IL-6 level in the poor-prognosis group were significantly higher than those in the favorable-prognosis group(P<0.05).For the prognostic diagnosis of gastric cancer,the area un-der the ROC curves(AUCs)was ranked from high to low:Th17/Treg ratio,Th17,Treg and IL-6 level,and the combined detection of these indicators yielded the highest AUC of 0.921.Conclusion:With the pro-gression of TNM stage,the levels of Th17,Treg,Th17/Treg ratio and IL-6 level significantly increase,which are closely associated with poor prognosis and combined detection of these markers demonstrates high diagnos-tic value for predicting GC prognosis.关键词
胃癌/临床分期/辅助性T细胞17/调节性T细胞/白细胞介素-6Key words
Gastric cancer/Clinical stage/Th17 cells/Regulatory T cells/Interleukin-6引用本文复制引用
徐榕蔓,葛仁美..Th17/Treg及IL-6在不同分期胃癌表达水平及其对预后的影响[J].河北医学,2026,32(6):984-990,7.基金项目
国家自然科学基金资助项目(81802347) （81802347）
南通市自然科学基金和社会民生科技项目(MSZ2023227) （MSZ2023227）
海安市人民医院院级科研项目(20336) （20336）
