河北医学2026，Vol.32Issue(6)：1007-1011,5.DOI:10.3969/j.issn.1006-6233.2026.06.020
血清ficolin-3 miRNA-124与颅脑外伤患者预后神经功能损伤程度的相关性分析
Correlation Analysis of Serum Ficolin-3 miRNA-124 Levels with the Degree of Neurological Injury in Patients with Craniocerebral Trauma
摘要
Abstract
Objective:To explore the correlation of serum ficolin-3,peripheral blood microRNA-124(miRNA-124)with the degree of neurological function injury in patients with craniocerebral trauma.Meth-ods:87 patients with craniocerebral trauma admitted to the hospital from March 2023 to December 2023 were included in the study group.The degree of neurological function injury in patients with craniocerebral trauma was evaluated by the Glasgow Coma Scale(GCS),who were divided into severe group(n=23),moderate group(n=34),and mild group(n=30).Meanwhile,53 healthy volunteers during the same period were in-cluded in the control group.Serum ficolin-3 was detected by enzyme-linked immunosorbent assay,and miR-NA-124 was detected by fluorescence quantitative PCR.The expression levels of serum ficolin-3 and miRNA-124 in each group were collected and compared.Pearson analysis was used to analyze the correlation of ser-um ficolin-3,miRNA-124 with the degree of neurological function injury in patients with craniocerebral trau-ma.Results:The GCS scores of the severe group were higher than those of the mild and moderate groups,and the GCS scores of the moderate group were higher than those of the mild group,with statistical significance(P<0.05).The serum ficolin-3 in the study group was lower than that in the control group,and miRNA-124 was higher than that in the control group,with statistical significance(P<0.05).The serum ficolin-3 in the severe group was lower than that in the mild and moderate groups,and miRNA-124 was higher than that in the mild and moderate groups,with statistical significance(P<0.05);the serum ficolin-3 in the moderate group was lower than that in the mild GCS score group,and miRNA-124 was higher than that in the mild GCS score group,with statistical significance(P<0.05).The serum ficolin-3 and miRNA-124 in patients with craniocerebral trauma and neurological injury were negatively correlated(r=-0.639,P<0.05);serum ficolin-3 was negatively correlated with the GCS scores in patients with craniocerebral trauma(r=-0.616,P<0.05),and miRNA-124 was positively correlated with the GCS scores(r=0.705,P<0.05).Conclusion:Se-rum ficolin-3 and miRNA-124 are related to the degree of neurological injury in patients with craniocerebral trauma.A decrease in serum ficolin-3 and an increase in miRNA-124 indicate more severe neurological inju-ry.关键词
颅脑外伤/ficolin-3/miRNA-124/神经功能损伤程度Key words
Craniocerebral injury/Ficolin-3/MiRNA-124/The degree of neurological injury引用本文复制引用
任晓琳,尹涛,陈建超..血清ficolin-3 miRNA-124与颅脑外伤患者预后神经功能损伤程度的相关性分析[J].河北医学,2026,32(6):1007-1011,5.基金项目
国家自然科学基金委员会资助项目(82104792) （82104792）
