黑龙江动物繁殖2026，Vol.34Issue(3)：12-19,8.DOI:10.19848/j.cnki.ISSN1005-2739.2026.06.0002
二甲双胍对卵母细胞成熟的作用机制研究
Mechanism of metformin on the maturation of oocytes
摘要
Abstract
In vitro oocyte maturation(IVM)technology is a core tool in the field of animal assisted reproduction and biotechnology,and the quality of oocyte maturation directly affects fertilization rate and embryonic developmental competence.Oxidative stress,mitochondrial dysfunction,disrupted energy metabolism and endocrine abnormalities can impair both nuclear and cytoplasmic maturation of oocytes.Metformin,a widely used antidiabetic drug,not only improves insulin resistance and glucose and lipid metabolism but may also influence oocyte maturation by regulating AMPK signaling,improving mitochondrial function,reducing reactive oxygen species levels,modulating granulosa cell energy metabolism and alleviating endocrine disturbances associated with hyperandrogenism.However,the effects of metformin are not unidirectional and could be influenced by factors as species,dose,exposure duration,culture system and cellular metabolic status.This review summarizes the effects of metformin on the maturation quality and developmental competence of the oocytes,highlighting the experimental evidence in promoting and inhibitory effects,AMPK-related molecular mechanisms,granulosa cell-oocyte metabolic cooperation,and possible reasons for discrepant findings among studies.This paper intended to provide a theoretical basis for further research and practical application of metformin in animal reproduction and reproductive medicine.关键词
二甲双胍/卵母细胞/体外成熟/线粒体/氧化应激/AMPK信号通路Key words
metformin/oocyte/in vitro maturation/mitochondrion/oxidative stress/AMPK signaling pathway分类
生物科学引用本文复制引用
孙才皓,杨树宝..二甲双胍对卵母细胞成熟的作用机制研究[J].黑龙江动物繁殖,2026,34(3):12-19,8.基金项目
吉林省科技发展计划项目(YDZJ202601ZYTS706) （YDZJ202601ZYTS706）
