湖南中医药大学学报2026，Vol.46Issue(6)：1198-1203,6.DOI:10.3969/j.issn.1674-070X.2026.06.015
"水郁折之"视角下胞葬作用与动脉粥样硬化斑块稳定性的中医辨治策略
TCM differentiation and treatment strategies for efferocytosis and atherosclerotic plaque stability from the perspective of"dispersing water stagnation"
摘要
Abstract
Atherosclerosis(AS)is a critical pathological basis for cardiovascular and cerebrovascular diseases.Plaque stability directly determines the prognosis,and efferocytosis dysfunction is the microscopic mechanism underlying plaque destabilization.In Chinese medicine(TCM),AS falls into the categories of vessel impediment,phlegm turbidity,and stasis obstruction.Its pathogenesis involves internal water stagnation,intertwined phlegm and blood stasis,and obstruction of the vessels,which corresponds to the pathological process consistent with the accumulation of pathological products resulting from efferocytosis dysfunction.This paper takes the theory of"dispersing water stagnation"as the entry point,reviews the modern mechanisms by which dysregulated efferocytosis affects AS plaque stability,and elucidates the intrinsic link between this theory and the disease pathogenesis.On this basis,it establishes the TCM treatment principles of dispersing stagnation and transforming turbidity,as well as unblocking the vessels and stabilizing plaques.Corresponding formulas are proposed,and their compatibility rationale and pattern-based modifications are analyzed.Furthermore,the mechanisms of action of these formulas are elucidated from multiple aspects,including regulation of efferocytosis pathways,inhibition of inflammation,modulation of lipid metabolism,and repair of plaque structure.Treating AS from the perspective of"dispersing water stagnation"integrates macroscopic pattern differentiation with microscopic mechanisms,enabling multi-target regulation of efferocytosis and AS plaque stabilization,thus providing a theoretical basis and clinical reference for the TCM prevention and treatment of this disease.关键词
水郁折之/胞葬作用/动脉粥样硬化/斑块稳定性/疏郁化浊/通脉稳斑Key words
dispersing water stagnation/efferocytosis/atherosclerosis/plaque stability/dispersing stagnation and trans-forming turbidity/unblocking the vessels and stabilizing plaques分类
医药卫生引用本文复制引用
胡雨生,狄可,窦智勇,付鑫磊,孙贺辰,孟天伟,客蕊.."水郁折之"视角下胞葬作用与动脉粥样硬化斑块稳定性的中医辨治策略[J].湖南中医药大学学报,2026,46(6):1198-1203,6.基金项目
黑龙江省中医药科研项目(ZYW2024-014). （ZYW2024-014）
