湖南中医药大学学报2026，Vol.46Issue(6)：1233-1238,6.DOI:10.3969/j.issn.1674-070X.2026.06.020
大续命汤加减治疗急性缺血性卒中(中风-中经络)的临床疗效观察
Clinical efficacy observation of modified Daxuming Decoction in treating acute ischemic stroke(stroke involving the meridians)
摘要
Abstract
Objective To observe the clinical efficacy of modified Daxuming Decoction in treating acute ischemic stroke(AIS)(stroke involving the meridians)with wind-phlegm and blood stasis obstruction pattern.Methods A prospective study was conducted on 76 patients with AIS(stroke involving the meridians)of wind-phlegm and blood stasis obstruction pattern admitted to Beijing Shunyi Hospital of Traditional Chinese Medicine from January 2023 to December 2024.They were divided into observation group and control group using a random number table method,with 38 cases in each group.The control group received conventional Western medicine treatment,while the observation group received modified Daxuming Decoction(one dose per day for 14 days)in addition to the conventional treatment.The total effective rate after treatment,as well as the National Institutes of Health Stroke Scale(NIHSS)score and Barthel Index(BI)score at 1-month and 6-month follow-up visits,was compared between the two groups.Additionally,the mean blood flow velocity(Vm)values of the anterior cerebral artery,middle cerebral artery,and posterior cerebral artery measured by transcranial Doppler,hemorheological parameters(whole blood low-shear viscosity,plasma viscosity,fibrinogen),high-sensitivity C-reactive protein(hs-CRP),TCM pattern score,and the incidence of adverse reactions were compared before and 14 days after treatment.Results After treatment,the total effective rate in the observation group was 97.37％,which was significantly higher than 76.32％in the control group(P<0.05).The NIHSS scores in the observation group were lower than those in the control group(P<0.05),while the BI scores were higher(P<0.05).After treatment,compared with the control group,the observation group showed increased Vm values in the anterior,middle,and posterior cerebral arteries(P<0.05),decreased hemorheological parameters(whole blood low-shear viscosity,plasma viscosity,fibrinogen)and hs-CRP levels(P<0.05),and reduced total TCM pattern scores as well as scores for primary symptoms(hemiplegia,facial deviation,dysphasia),and secondary symptoms(fatigue,loss of appetite,excessive phlegm)(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Daxuming Decoction combined with conventional Western medicine can effectively improve neurological function,daily living ability,and cerebral blood flow perfusion,and reduce TCM pattern scores in patients with AIS(stroke involving the meridians)and wind-phlegm and blood stasis obstruction pattern,with good safety.关键词
急性缺血性卒中/大续命汤/中经络/风痰瘀阻证/神经功能/血液流变学Key words
acute ischemic stroke/Daxuming Decoction/stroke involving the meridians/wind-phlegm and blood stasis pattern/neurological function/hemorheology分类
医药卫生引用本文复制引用
丁雪霏,肖阳春..大续命汤加减治疗急性缺血性卒中(中风-中经络)的临床疗效观察[J].湖南中医药大学学报,2026,46(6):1233-1238,6.基金项目
北京市医管局培育计划项目(PZ2023023) （PZ2023023）
北京中医医院顺义医院院级课题项目(SYYJ-201810). （SYYJ-201810）
