华侨大学学报（自然科学版）2026，Vol.47Issue(4)：482-490,9.DOI:10.11830/ISSN.1000-5013.202603027
青藤碱-没食子酸纳米颗粒对脂多糖致小鼠急性肺损伤的保护作用
Protective Effect of Sinomenine-Gallic Acid Nanoparticles on Lipopolysaccharide Induced Acute Lung Injury of Mice
摘要
Abstract
To explore effective and specific drugs for acute lung injury(ALI),sinomenine-gallic acid self-as-sembled nanoparticles(SGNPs)were prepared using one-step self-assembly method,and their protective effects and mechanisms against ALI were evaluated.The results showed that the average hydrodynamic diame-ter of SGNPs was(67.00±3.61)nm with a uniform spherical morphology.The hemolysis rate of SGNPs at a concentration of 0.8 mmol·L-1 was below the 5% safety threshold.,meeting the requirements for intrave-nous administration.SGNPs alleviated pathological damage in lung tissue,reduced inflammatory cell infiltra-tion,and significantly decreased the levels of serum IL-1β and IL-6,as well as the mRNA expression of IL-1β,IL-6,iNOS,and TNF-α in lung tissue.SGNPs could inhibit the phosphorylation levels of ERK,IκBα and NF-κB p65 in lung tissue,and SGNPs exhibited good biosafety both in vitro and in vivo.SGNPs exerted anti-inflammatory effects by regulating the MAPK/NF-κB signaling pathway,with simple preparation and excellent biocompatibility.关键词
急性肺损伤/炎症/青藤碱/没食子酸/自组装纳米颗粒Key words
acute lung injury/inflammation/sinomenine/gallic acid/self-assembled nanoparticles分类
通用工业技术引用本文复制引用
邱依婷,刘玫言,岳智涵,辛书竞,汪淳淳,刁勇,李维娜..青藤碱-没食子酸纳米颗粒对脂多糖致小鼠急性肺损伤的保护作用[J].华侨大学学报（自然科学版）,2026,47(4):482-490,9.基金项目
国家自然科学基金海峡联合基金资助项目(U1405215) （U1405215）
