家畜生态学报2026，Vol.47Issue(6)：109-114,6.DOI:10.3969/j.issn.1673-1182.2026.06.015
外泌体调控哺乳动物体外胚胎生产的研究进展
Research Progress of Exosomes Regulating Mammalian Embryo Production in vitro
摘要
Abstract
The replication of in vivo physiological conditions and identification of effective regulatory factors for embryo development are crucial aspects in the production of embryos in vitro.Exosomes,a subtype of extracellular vesicles ranging from 30 to 150nm,are released by various cell types,and serve as carriers for intercellular communication,containing abundant proteins,lipids,and diverse RNA mole-cules.As mediators of intercellular communication,exosomes play significant roles in oocyte maturation,fertilization,and preimplantation embryo development.It has been confirmed that exosomes exist in follic-ular fluid,uterine fluid,and fallopian tube epithelial cells of mammals.Addition of exosomes to the oocyte cul-ture system can regulate oocyte maturation process effectively while enhancing the rate of in vitro fertilization and promoting preimplantation embryo development.This paper aims to introduce the functions of exosomes during mammalian oocyte maturation,fertilization,and preimplantation embryo development with the purpose of provi-ding suggestions on utilizing exosomes to optimize the in vitro embryo culture system.关键词
体外胚胎生产/外泌体/卵母细胞/体外受精Key words
in vitro embryo production/exosomes/oocyte/in vitro fertilization分类
农业科技引用本文复制引用
韩艺伟,赵杨杨,王香南,张子敬,高留涛,刘雯,鲁立刚,王二耀..外泌体调控哺乳动物体外胚胎生产的研究进展[J].家畜生态学报,2026,47(6):109-114,6.基金项目
河南省肉牛产业技术体系项目(HARS-22-13-S) （HARS-22-13-S）
财政部与农业农村部-国家现代农业产业技术体系(CARS-37) （CARS-37）
河南省重大科技专项(221100110200) （221100110200）
河南省农业科学院科技创新团队项目(2023TD25) （2023TD25）
