基础医学与临床2026，Vol.46Issue(7)：1004-1008,5.DOI:10.16352/j.issn.1001-6325.2026.07.1004
NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展
Research progress in the role of NLRP3 inflammasome in hepatic ischemia-reperfusion injury
摘要
Abstract
Hepatic ischemia-reperfusion injury(HI/RI)is an inevitable pathophysiological process in liver surgery and is an important factor leading to severe postoperative complications.Its mechanism is complex,involving multi-ple pathways such as oxidative stress,intracellular calcium overload,and inflammatory response.In recent years,as an important regulatory hub of the innate immune response,the NOD-like receptor thermal protein domain asso-ciated protein 3(NLRP3)inflammasome has played a core role in HI/RI.This article reviews the structure and function of the NLRP3 inflammasome,its activation mechanism in HI/RI to identify the core role of this molecule and to explore the research status and challenges of various intervention strategies targeting NLRP3,providing new theoretical perspectives and orientation for clinical prevention and treatment of HI/RI.关键词
炎性小体/肝缺血/再灌注损伤/细胞焦亡/炎性反应/靶向治疗Key words
inflammasome/hepatic ischemia-reperfusion injury/pyroptosis/inflammatory response/targeted therapy分类
医药卫生引用本文复制引用
刘翠玲,于树娜..NLRP3炎性小体在肝缺血/再灌注损伤中作用的研究进展[J].基础医学与临床,2026,46(7):1004-1008,5.基金项目
山东省医药卫生科技发展计划(202001020642) （202001020642）
