基础医学与临床2026，Vol.46Issue(7)：1009-1013,5.DOI:10.16352/j.issn.1001-6325.2026.07.1009
肿瘤相关内含子增强子区SNPs调控机制的研究进展
Research progress in the regulatory mechanism of tumor-associated intronic enhancer region SNPs
摘要
Abstract
single nucleotide polymorphisms(SNPs)are the most common genetic polymorphisms.Intronic enhancer region SNPs(IER-SNPs)can influence the progress of carcinomaigenesis and progression of breast cancer,colorec-tal cancer,lung cancer and other carcinomas by multiple approaches including influencing the transcription factor binding,promoter-enhancer interactions and mediating the enhancer-promoter switching effect and so on.By sorting out the regulatory mechanisms of IER-SNPs on tumors,it can provide references for screening tumor-associated IER-SNPs formation and development and or research on regulatory mechanisms of these IER-SNPs.关键词
肿瘤/内含子/单核苷酸多态性(SNP)/增强子/调控Key words
carcinoma/intron/single nucleotide polymorphism(SNP)/enhancer/regulation分类
医药卫生引用本文复制引用
李贤群,池雨欣,苗家鸣,齐晓璐,魏童,杨卫红..肿瘤相关内含子增强子区SNPs调控机制的研究进展[J].基础医学与临床,2026,46(7):1009-1013,5.基金项目
第二批河南省专创融合特色示范课程(豫教2024ZCRH05) （豫教2024ZCRH05）
郑州大学大学生创新创业计划训练项目(2024cxcy510) （2024cxcy510）
河南省重点研发与推广专项(科研攻关)(222102310186) （科研攻关）
