中国当代医药2026，Vol.33Issue(13)：56-60,5.DOI:10.3969/j.issn.1674-4721.2026.13.12
结直肠癌患者癌胚抗原的影响因素分析
Analysis of the influencing factors of carcinoembryonic antigen in patients with colorectal cancer
摘要
Abstract
Objective To explore the influencing factors of carcinoembryonic antigen(CEA)in patients with colorectal can-cer.Methods A total of 180 patients with colorectal cancer who were admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University,Jiamusi University Affiliated First Hospital,and Qiqihar Medical University Affiliated Third Hospital from January 2021 to December 2023 were selected as the research subjects.The levels of serum 25-hydroxyvitamin,tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were detected by enzyme-linked immunosorbent assay;the levels of CEA,carbohydrate antigen 199(CA19-9),and carbohydrate antigen 724(CA72-4)were detected by chemiluminescence method;and the level of insulin-like growth factor bindin g protein 3(IGFBP3)was detected by double-antibody sandwich method.CEA was used as the dependent variable,and various serological indicators,clinical pathological features(including vitamin D intake history)and other factors were used as independent variables for univariate analysis and multivariate linear regression analysis.Results The single-factor analysis showed that patients with tumor diameter≥5 cm,lymph node metastasis,TNM stage Ⅲ-Ⅳ,age≥60 years,body mass index(BMI)≥24 kg/m2,and insufficient vitamin D intake had higher CEA levels than the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in CEA levels between male and female patients(P＞0.05).Cor-relation analysis showed that CEA was negatively correlated with 25-hydroxyvitamin and IGFBP3,positively correlated with CA19-9 and CA72-4(P＜0.05),and had no correla-tion with TNF-α and IL-6(P＞0.05).The results of mul-tivariate factor analysis showed that 25-hydroxyvitamin(B=-0.523,t=5.500,95%CI:-0.715--0.331),TNM stage(B=1.852,t=3.891,95%CI:0.946-2.758),tumor diameter(B=1.246,t=3.124,95%CI:0.458-2.034),lymph node metastasis(B=1.083,t=2.876,95%CI:0.321-1.845),age(B=0.864,t=2.621,95%CI:0.213-1.515),and BMI(B=0.635,t=2.185,95%CI:0.102-1.168)were independent influencing factors of CEA in patients with colorectal cancer(P＜0.05).Conclusion The serum 25-hydroxyvitamin level was negatively correlated with the expression of CEA in patients with colorectal cancer.It may participate in tumor progression by regulating the IGF signaling pathway and has the potential to be used as an auxiliary monitoring indicator related to CEA.TNM stage,tumor diameter,lymph node metastasis,age,and BMI were also independent influencing factors of CEA and could provide references for the diagnosis,treatment,and prognosis assessment of colorectal cancer.关键词
结直肠癌/血清25-羟维生素D/肿瘤标志物/胰岛素样生长因子结合蛋白3Key words
Colorectal cancer/Serum 25-hydroxyvitamin D/Tumor markers/Insulin-like growth factor binding protein 3分类
医药卫生引用本文复制引用
宋传芳,艾江,张杰,孙哲宇,陈爱东..结直肠癌患者癌胚抗原的影响因素分析[J].中国当代医药,2026,33(13):56-60,5.基金项目
黑龙江省卫生健康委科研课题项目(20210303030277). （20210303030277）
