中国当代医药2026，Vol.33Issue(15)：53-56,4.DOI:10.3969/j.issn.1674-4721.2026.15.11
甲钴胺联合依帕司他治疗糖尿病周围神经病变的效果
Effect of Mecobalamin and Epalrestat in the treatment of diabetic pe-ripheral neuropathy
摘要
Abstract
Objective To study the clinical effect of Mecobalamin combined with Epalrestat in the treatment of patients with diabetes peripheral neuropathy.Methods A total of 100 patients with diabetic peripheral neuropathy admitted to Shangrao Central Hospital from April 2024 to April 2025 were selected as the study subjects.They were divided into the experimental group(50 cases)and the control group(50 cases)according to random number table method.The control group received conventional Mecobalamin treatment,while the experimental group received Mecobalamin combined with Epalrestat treatment.The efficacy,nerve conduction velocity(NCV),and adverse reactions of the two groups were compared and analyzed.Results The effective rate of the experimental group after treatment was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the NCV of the tibial nerve,common peroneal nerve,and plantar nerve in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Mecobalamin is effective in the treatment of patients with diabetes peripheral neuropathy.The combined use of Epalrestat in this process can further enhance the efficacy,promote the increase of patients'nerve conduction velocity,and ensure the recovery effect of patients,which is worthy of clinical promotion.关键词
甲钴胺/依帕司他/糖尿病周围神经病变/神经传导速度Key words
Mecobalamin/Epalrestat/Diabetic peripheral neuropathy/Nerve conduction velocity分类
医药卫生引用本文复制引用
杨克华,泮华,李巧巧..甲钴胺联合依帕司他治疗糖尿病周围神经病变的效果[J].中国当代医药,2026,33(15):53-56,4.基金项目
江西省卫生健康委科技计划项目(SKJP220211187) （SKJP220211187）
江西省上饶市科技计划项目(20241CZDX61). （20241CZDX61）
