中国当代医药2026，Vol.33Issue(15)：92-96,5.DOI:10.3969/j.issn.1674-4721.2026.15.20
不同剂量早期肠内营养方案对使用血管活性药物的老年重症患者的影响
Effect of different doses of early enteral nutrition regimens on elderly crit-ically ill patients receiving vasoactive drugs
摘要
Abstract
Objective To explore the effects of different doses of early enteral nutrition(EEN)regimens on elderly critically ill patients using vasoactive drugs.Methods A total of 132 elderly critically ill patients admitted to Shangrao People's Hos-pital from January 2024 to April 2025,who were treated with vasoactive drugs to control shock after fluid resuscitation and began to receive EEN at the same time,were divided into a low-energy intake group and a high-energy intake group by the random number table method,with 66 cases in each group,a total of 4 patients in the low-energy intake group dropped out.The low-energy intake group was given 25%-70%of the target energy,while the high-energy intake group was given more than 70%of the target energy.The tolerance of EEN,ICU hospitalization time,hospitalization cost,90-day all-cause mortality rate,the duration of vasoactive drug and EEN combination use,the equivalent dose of norepinephrine(NE)at 12 and 24 hours after starting EEN,and the maximum dose change(μg/min,μg/[kg·min])were compared between the two groups.Results For elderly critically ill patients receiving vasoactive drugs(with a median NE of 0.15 μg/[kg·min]),early extubation was initiated.The intolerance rate in the low-energy intake group was lower than that in the high-energy intake group,the duration of combined use of vasoactive drugs and EEN was shorter than that in the high-energy intake group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in the NE equiva-lent and weight correction NE equivalent maximum doses(doses for 12 and 24 hours),ICU hospitalization time,hospitalization cost,and 90-day all-cause mortality between the two groups(P＞0.05).Conclusion For elderly critically ill patients who received vasoactive drugs(with a median NE of 0.15 μg/[kg·min]),after shock control,EEN can be initiated.Low energy intake not only improves tolerance but also shortens the duration of the combined use of vasoactive drugs and EEN.关键词
血管活性药物/老年重症患者/早期肠内营养/耐受性/营养方案Key words
Vasoactive drugs/Elderly critically ill pa-tients/Early enteral nutrition/Tolerance/Nutrition regimens分类
医药卫生引用本文复制引用
周琴,李博,邱永军,徐粼,甘露..不同剂量早期肠内营养方案对使用血管活性药物的老年重症患者的影响[J].中国当代医药,2026,33(15):92-96,5.基金项目
2024年江西省医院药学专项研究基金(2024-ZXYJ13) （2024-ZXYJ13）
上饶市科技计划项目(20242CZDX31). （20242CZDX31）
