摘要
Abstract
Objective To investigate the correlation of peripheral blood γ-glutamyl transferase to platelet ratio(GPR),angiopoietin-like protein 2(ANGPTL2)level,and lipid metabolism with coronary artery lesions in patients with essential hypertension(EH)complicated by unstable angina pectoris(UAP).Methods A total of 80 patients with EH complicated by UAP(EH+UAP group)were enrolled.Additionally,80 patients with EH alone(EH group),80 patients with UAP alone(UAP group),and 80 healthy controls(healthy group)were included for comparison.The levels of peripheral blood GPR and ANGPTL2,and lipid metabolism parameters[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)]were compared among groups.Subgroup analyses were performed within the EH+UAP group based on the severity of coronary artery lesions.Results Peripheral blood GPR and ANGPTL2 level in the EH+UAP group were significantly higher than those in the UAP group,EH group,and healthy group(all P＜0.05).LDL-C level in the EH+UAP group was also significantly higher than that in the other three groups(all P＜0.05).Subgroup analysis showed that in patients with severe lesions(within the EH+UAP group),peripheral blood GPR and ANGPTL2 level were significantly higher than those in patients with mild or moderate lesions(all P＜0.05).Levels of TC,TG,and LDL-C were significantly higher,while HDL-C was significantly lower in patients with severe lesions compared with mild or moderate lesions(all P＜0.05).Spearman correlation analysis revealed that peripheral blood GPR,ANGPTL2,and LDL-C levels were positively correlated with the severity of coronary artery lesions(rs=0.514,0.577 and 0.489,respectively;all P＜0.001).Conclusion Changes in peripheral blood GPR,ANGPTL2,and LDL-C level can reflect,to some extent,the coronary artery lesion burden in patients with EH complicated by UAP.Combined monitoring of these indicators may assist in evaluating the severity of coronary artery lesions and providing reference for clinical risk stratification.关键词
γ-谷氨酰基转移酶与血小板比值/血管生成素样蛋白2/血脂/原发性高血压/不稳定型心绞痛Key words
γ-glutamyl transferase to platelet ratio/angiopoietin-like protein 2/blood lipid/essential hypertension/unstable angina pectoris分类
医药卫生
