检验医学与临床2026，Vol.23Issue(12)：1646-1650,5.DOI:10.3969/j.issn.1672-9455.2026.12.010
藤黄健骨胶囊联合阿法骨化醇治疗老年性骨质疏松症的疗效及对血清IGF-1、LCN2水平的影响
Efficacy of Tenghuang Jiangu capsule combined with alfacalcidol in the treatment of senile osteoporosis and its influence on serum IGF-1 and LCN2 levels
摘要
Abstract
Objective To investigate the efficacy of Tenghuang Jiangu capsule combined with alfacalcidol in the treatment of senile osteoporosis(OP)and its influence on serum levels of insulin-like growth factor-1(IGF-1)and lipocalin-2(LCN2).Methods A total of 122 patients with senile OP admitted to the hospital from October 2022 to August 2024 were selected as the study subjects and randomly divided into a control group(treated with alfacalcidol)and a combination group(treated with Tenghuang Jiangu capsule plus alfa-calcidol)using the random number table method,with 61 cases in each group.Clinical efficacy,bone mineral density(BMD),bone markers[osteocalcin(BGP),bone alkaline phosphatase(BALP),and tartrate-resistant acid phosphatase 5b(TRACP-5b)],serum levels of IGF-1 and LCN2,and adverse reactions were compared between the two groups.Results The total effective rate in the combination group was significantly higher than that in the control group(P<0.05).After treatment,BMD and levels of IGF-1,BGP and BALP in the combination group were significantly higher than those in the control group(P<0.05),whereas levels of TRACP-5b and LCN2 were significantly lower than those in the control group(P<0.05).No statistically sig-nificant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).Con-clusion Tenghuang Jiangu capsule combined with alfacalcidol demonstrates definite clinical efficacy in the treatment of senile OP.This combined therapy can increase BMD,improve bone markers and serum IGF-1 and LCN2 levels,and exhibit a favorable safety profile.关键词
藤黄健骨胶囊/阿法骨化醇/老年性骨质疏松症/胰岛素样生长因子-1/脂质运载蛋白2Key words
Tenghuang Jiangu capsule/alfacalcidol/senile osteoporosis/insulin-like growth factor-1/lipocalin-2分类
医药卫生引用本文复制引用
于芳,吴勇,蔡龙..藤黄健骨胶囊联合阿法骨化醇治疗老年性骨质疏松症的疗效及对血清IGF-1、LCN2水平的影响[J].检验医学与临床,2026,23(12):1646-1650,5.基金项目
陕西省重点研发计划项目(2021ZDXM-SF-028) （2021ZDXM-SF-028）
陕西省咸阳市第一人民医院2023年科技计划项目(IITLC-2023031). （IITLC-2023031）
