张嘉茜 1胡纳新 1周毅 1侯波 1支建梅 2武文平3
作者信息
- 1. 北京中医药大学东方医院秦皇岛医院 影像科,河北 秦皇岛 066000
- 2. 北京中医药大学东方医院秦皇岛医院 脑病二科,河北 秦皇岛 066000
- 3. 北京中医药大学东方医院秦皇岛医院 检验科,河北 秦皇岛 066000
- 折叠
摘要
Abstract
Objective To investigate the predictive value of CT cerebral perfusion imaging parameters com-bined with serum microRNA-103(miR-103)and microRNA-106a-5p(miR-106a-5p)for poor prognosis in pa-tients with acute ischemic stroke(AIS).Methods A total of 146 patients with AIS treated in the hospital from December 2021 to December 2024 were selected as the study subjects and divided into a mild group,a moderate group and a severe group according to the severity of the disease.Before treatment,all patients un-derwent CT cerebral perfusion imaging,and mean transit time(MTT)and time to peak(TTP)were ob-tained.Based on the short-term prognosis assessment at 3 months after treatment,the patients were divided into a good prognosis group and a poor prognosis group.Prior to treatment,the serum expression levels of miR-103 and miR-106a-5p were measured by quantitative real-time polymerase chain reaction.Baseline data of the patients were compared.Multivariate Logistic regression analysis was performed to identify the factors as-sociated with poor prognosis in patients with AIS.Receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of serum miR-103,miR-106a-5p,MTT and TTP for poor prognosis in patients with AIS.Results The expression levels of serum miR-103 and miR-106a-5p in the severe group were higher than those in the mild and moderate groups,and MTT and TTP in the severe group were longer than those in the mild and moderate groups;additionally,the expression levels of serum miR-103 and miR-106a-5p in the moderate group were higher than those in the mild group,and MTT and TTP in the moderate group were lon-ger than those in the mild group,and the differences were statistically significant(P<0.05).The expression levels of serum miR-103 and miR-106a-5p,and the National Institutes of Health Stroke Scale(NIHSS)score at admission in the poor prognosis group were higher than those in the good prognosis group,MTT and TTP were longer than those in the good prognosis group,and the maximum lesion diameter was larger than that in the good prognosis group,and the differences were statistically significant(P<0.05).Serum miR-103,miR-106a-5p,NIHSS score at admission,MTT,and TTP were identified as factors associated with poor prognosis in AIS patients(P<0.05).The areas under the curve(AUCs)of MTT,TTP,serum miR-103,serum miR-106a-5p,and the combination of the four indicators for predicting poor prognosis in AIS patients were 0.876,0.825,0.830,0.791,and 0.937 respectively.The AUC of the combined prediction was significantly greater than that of each individual indicator(Zcombination vs.MTT=2.182,P=0.029;Zcombination vs.TTP=2.734,P=0.006;Zcombination vs.miR-103=2.643,P=0.008;Zcombination vs.miR-106a-5p=4.003,P<0.001).Conclusion The expression lev-els of serum miR-103 and miR-106a-5p are significantly elevated in AIS patients.MiR-103 and miR-106a-5p are closely associated with disease severity and short-term prognosis.CT cerebral perfusion imaging parame-ters combined with serum miR-103 and miR-106a-5p demonstrate higher predictive value for poor prognosis in AIS patients.关键词
微小RNA-103/微小RNA-106a-5p/急性缺血性脑卒中/CT脑灌注成像/预后不良Key words
microRNA-103/microRNA-106a-5p/acute ischemic stroke/CT cerebral perfusion ima-ging/poor prognosis分类
医药卫生
