昆明医科大学学报2026，Vol.47Issue(6)：33-43,11.DOI:10.12259/j.issn.2095-610X.S20260604
易感与弹性吸毒人群的童年期负性事件与FKBP5、ACTH、BDNF和皮质醇的相关性
Childhood Adverse Events and Their Correlation with FKBP5,ACTH,BDNF,and Cortisol in Susceptible and Resilient Drug-using Populations
摘要
Abstract
Objective To investigate the association between adverse childhood experiences(ACEs)and adverse health outcomes(AHOs),and to compare the levels of FKBP5,ACTH,cortisol,and BDNF between susceptible and resilient individuals exposed to ACEs during childhood.Methods Based on a cohort of 405 individuals with substance use disorder in Yunnan Province established from January to July 2021,a nested case-control study was conducted.FKBP5,ACTH,cortisol,and BDNF levels were detected in the control group,resilient group and susceptible group.Whole-genome sequencing(WGS)technology was used to identify mutation sites Descriptive,univariate and multivariate analyses were conducted using SPSS 24.0 and R Studio version 4.3.1.n Results Significant differences in FKBP5 levels were found between the control group(n=7)and resilient groups(n=14)[(4.67±1.08)vs.(6.86±1.87)ng/mL,P＜0.05].Compared with the control group,ACTH levels in the susceptible group(n=14)were elevated[(54.05±8.75)pg/mL,P＜0.05];compared with the susceptible group,ACTH levels in the resilient group were elevated[(67.28±8.36)pg/mL,P＜0.05].Cortisol levels showed significant differences between the control and susceptible groups[(254.92±70.46)vs.(278.50±49.60)nmol/L,P＜0.05]and between the susceptible and resilient groups[(278.50±49.60)vs.(406.27±72.07)nmol/L,P＜0.05].Multivariate logistic regression analysis showed that,with the control group as reference,the resilient group had significant differences in FKBP5,cortisol,and rs34224676 genotype levels(OR=3.62,95％CI:1.36～9.64,P＜0.05;OR=1.02,95％CI:1.00～1.04,P＜0.05;OR=185.34,95％CI:69.56～493.83,P＜0.05).Conclusion Individuals with substance use disorder exposed to ACEs exhibited higher levels of FKBP5,ACTH,and cortisol compared to those without ACEs exposure.Under ACEs exposure,the expression of FKBP5,cortisol,and the SNP locus rs34224676 in individuals with substance use disorder may be associated with the resilience phenomena.关键词
童年期负性事件/FKBP5/ACTH/弹性/易感性Key words
Adverse childhood experiences/FKBP5/ACTH/Resilience/Susceptibility分类
医药卫生引用本文复制引用
张字瑞,石宏,雷万洋,陈维嘉,唐乐天,李静,夏雪山..易感与弹性吸毒人群的童年期负性事件与FKBP5、ACTH、BDNF和皮质醇的相关性[J].昆明医科大学学报,2026,47(6):33-43,11.基金项目
云南省应用基础研究项目(202301AY070001-258) （202301AY070001-258）
国家自然科学基金(72274086) （72274086）
云南省中青年学术和技术带头人后备人才项目(202205AC160064) （202205AC160064）
昆明医科大学一流学科团队(2024XKTDYS09) （2024XKTDYS09）
