昆明医科大学学报2026，Vol.47Issue(6)：162-172,11.DOI:10.12259/j.issn.2095-610X.S20260617
瘤内微生物代谢对肿瘤的双重效应
Dual Effects of Intratumoral Microbial Metabolism on Tumors
摘要
Abstract
Research has confirmed that tumor tissues are not in a sterile state,but rather host microbial communities with tumor-specific characteristics.These intratumoral microorganisms not only directly promote or inhibit tumorigenesis themselves,but can also influence tumor development and therapeutic responses through their active metabolic activities.This review examines the effects and mechanisms of intratumoral microbial metabolism on tumors from both pro-tumoral and anti-tumoral perspectives,and summarizes novel strategies for tumor prevention and treatment based on intratumoral microbial metabolism.The precise regulatory network of intratumoral microbial metabolism on tumors requires further investigation.Elucidating its dual effects and molecular mechanisms on tumors is expected to provide new directions for tumor prevention and treatment.关键词
瘤内微生物/代谢/肿瘤/治疗Key words
Intratumoral microbiota/Metabolism/Tumor/Therapy分类
医药卫生引用本文复制引用
郭天轶,杨冉,黄新伟..瘤内微生物代谢对肿瘤的双重效应[J].昆明医科大学学报,2026,47(6):162-172,11.基金项目
国家自然科学基金(82260486) （82260486）
云南省重大科技专项基金(202302AA310039-02) （202302AA310039-02）
