口腔颌面外科杂志2026，Vol.36Issue(3)：206-213,8.DOI:10.12439/kqhm.1005-4979.2026.03.005
口腔颌面部恶性肿瘤生物样本库的建设与应用:基于1 138例患者的初步预后分析
Establishment and application of a biobank for oral and maxillofacial malignant tumors:Preliminary prognostic analysis of 1 138 patients
摘要
Abstract
Objective:To explore the construction model of a biobank for oral and maxillofacial malignant tumors and its application value in clinical prognosis research,and to analyze the risk factors influencing patient prognosis.Methods:The establishment and operation of the biobank for oral and maxillofacial malignant tumors at Nanjing Stomatological Hospital were summarized.Based on this biobank,clinical data of 1 138 patients with oral and maxillofacial malignant tumors who underwent surgical treatment at the hospital from January 2013 to December 2018 were retrospectively analyzed.A clinicopathological database was established and follow-up was conducted.Overall survival rate was calculated using the Kaplan-Meier method,univariate analysis was performed using the Log-rank test,and multivariate analysis was performed using the Cox proportional hazards regression model.Results:A standardized biobank for oral and maxillofacial malignant tumors integrating sample collection,processing,storage,quality control,and clinical follow-up was established at our center.As of December 2023,the biobank had enrolled a total of 2 594 patients.A total of 1 138 patients were included in this study,with a mean follow-up time of 45.37±21.16 months.The overall 1-,3-,and 5-year survival rates were 89.67%,80.02%,and 76.04%,respectively.Multivariate analysis showed that age≥60 years[hazard ratio(HR)=1.439,95%confidence interval(CI):1.108‒1.868],tumor recurrence(HR=2.679,95%CI:1.962‒3.657),and lymph node metastasis(HR=3.312,95%CI:2.409‒4.554)were independent risk factors for overall survival(P<0.01).Conclusion:The standardized biobank for oral and maxillofacial malignant tumors established at our center provides important platform support for relevant clinical and translational research.Clinical prognostic analysis based on this biobank shows that age≥60 years,tumor recurrence,and lymph node metastasis are independent risk factors for patient prognosis,which has significant guiding value for risk stratification and individualized treatment.关键词
生物样本库/口腔颌面部恶性肿瘤/预后分析Key words
biobank/oral and maxillofacial malignant tumors/prognostic analysis分类
医药卫生引用本文复制引用
王玉凤,黄晓峰,翁佩,韩伟,泥艳红,胡勤刚..口腔颌面部恶性肿瘤生物样本库的建设与应用:基于1 138例患者的初步预后分析[J].口腔颌面外科杂志,2026,36(3):206-213,8.基金项目
国家自然科学基金(82473178) （82473178）
