临床输血与检验2026，Vol.28Issue(3)：425-429,5.DOI:10.3969/j.issn.1671-2587.2026.03.020
一例IgM+IgG型抗-K抗体鉴定与分析
A Case of Mixed IgM and IgG Anti-K Antibody:Identification and Clinical Implications
康世蓉 1王丹 1袁小华 1陆红芹 1李苏亮1
作者信息
- 1. 西安医学院第一附属医院,陕西 西安 710000
- 折叠
摘要
Abstract
Objective To identify the specificity,immunoglobulin subclass and titer of an anti-K antibody detected in a patient with a positive irregular antibody screen,and to analyze potential etiological factors contributing to its formation.Methods ABO blood grouping and Rh phenotyping were performed using standard serological methods.Irregular antibody screening and identification were carried out by normal saline(NS)tube test and microcolumn gel test(MGT).Crossmatching was conducted using NS,MGT,and manual polybrene test(MPT).The serum was treated with 2-mercaptoethanol(2-ME)to determine the immunoglobulin class and titer of the antibody.Results The irregular antibody screen was positive,and the antibody was specifically identified as anti-K.It was characterized as a mixed IgM and IgG isotypes,with an IgM titer of 2 and an IgG titer of 256.Conclusion Utilization of suitable laboratory techniques allows for the accurate detection of IgM+IgG anti-K antibodies,providing a guarantee for safe clinical transfusion.关键词
Kell血型/抗-K抗体/抗体鉴定/IgM抗体/IgG抗体Key words
Kell blood group/Anti-K antibody/Antibody identification/IgM antibody/IgG antibody分类
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康世蓉,王丹,袁小华,陆红芹,李苏亮..一例IgM+IgG型抗-K抗体鉴定与分析[J].临床输血与检验,2026,28(3):425-429,5.
