临床误诊误治2026，Vol.39Issue(12)：53-58,6.DOI:10.3969/j.issn.1002-3429.2026.12.009
软骨多参数磁共振成像对膝骨关节炎诊断及严重程度评估的应用研究
Application of cartilage multi-parametric magnetic resonance imaging in the diagnosis and severity assessment of knee osteoarthritis
摘要
Abstract
Objective To explore the application value of multiparametric magnetic resonance imaging of cartilage in the diagnosis and severity assessment of knee osteoarthritis(KOA).Methods We selected 108 patients with KOA diagnosed at the Second Hospital of Shijiazhuang City from January 2023 to December 2024 as study subjects(observation group),and divided them into mild group(n=50)and severe group(n=58)according to Kellgren-Lawrence(K-L)grading criteria.Another 108 healthy subjects undergoing physical examination in the same period were selected as control group.All candidates underwent cartilage multiparametric magnetic resonance imaging and the T1ρ value,T2 value,T2*value,and apparent diffusion coefficient(ADC)were compared among different groups.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of knee cartilage T1ρ value,T2 value,T2*value and ADC in KOA.The relationship of T1-ρ value,T2 value,T2*value,ADC,with Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score and the Whole-Organ Magnetic Resonance Imaging Score(WORMS)cartilage morphology score in patients with KOA was analyzed by Pearson correlation.Results The T1ρ value,T2 value,T2*value and ADC of cartilage in observation group were higher than those in control group(P＜0.01).ROC curve analysis showed that the sensitivity,specificity and the area under the curve(AUC)of T1-ρ value,cartilage T2 value and T2*value combined with ADC for the diagnosis of KOA were 90.12％,51.82％and 0.893,respectively.The T1-ρ value,T2 value,T2*value and ADC of cartilage in severe group were higher than those in mild group(P＜0.01),and the WOMAC score and WORMS cartilage morphology score in severe group were higher than those in mild group(P＜0.01).By Pearson correlation analysis,T1-ρ value,T2 value,T2*value and ADC of knee cartilage in patients with KOA were positively correlated with WOMAC score and WORMS cartilage morphology score(P＜0.01).Conclusion T1-ρ value,T2 value and T2*value measured by multiparametric magnetic resonance imaging combined with ADC have a certain suggestive role in the diagnosis of KOA,and are correlated with the severity of KOA.关键词
膝骨关节炎/软骨/磁共振成像/麦克马斯特大学骨关节炎指数/全器官磁共振成像系统/受试者工作特征Key words
knee osteoarthritis/cartilage/magnetic resonance imaging/Western Ontario and Mcmaster Universities Osteothritis Index/Whole-Organ Magnetic Resonance Imaging System/receiver operating characteristic引用本文复制引用
刘胜菊,赵振英,耿玉洁,田会,刘娜,赵新蕊..软骨多参数磁共振成像对膝骨关节炎诊断及严重程度评估的应用研究[J].临床误诊误治,2026,39(12):53-58,6.基金项目
河北省医学科学研究课题计划项目(20251096) （20251096）
石家庄市科技计划自筹资金项目(2414608003) （2414608003）
