临床误诊误治2026，Vol.39Issue(12)：92-96,5.DOI:10.3969/j.issn.1002-3429.2026.12.015
生肌玉红膏联合解毒洗剂治疗糖尿病足气阴两虚证临床效果观察
Clinical effect of Shengji Yuhong ointment combined with Jiedu lotion on diabetic foot with Qi and Yin deficiency syndrome
摘要
Abstract
Objective To investigate the therapeutic effect of Shengji Yuhong ointment combined with Jiedu lotion in the treatment of diabetic foot with Qi and Yin deficiency syndrome.Methods A retrospective analysis was conducted on the data of 60 diabetic foot patients admitted to Pingdingshan Hospital of Traditional Chinese Medicine from December 2022 to February 2025.According to different treatment methods,they were divided into the control group and the observation group.The control group received conventional treatment,while the observation group was supplemented with Shengji Yuhong ointment and Jiedu lotion on the basis of the control group.The clinical effect,adverse reactions,wound healing conditions(the time to the first appearance of granulation tissue and the time to wound healing),changes in wound area and total score of TCM syndromes before and after treatment,changes in inflammatory response indicators such as C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)before and after treatment,and levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),and endostatin(ES)was compared between the two groups.Results The total effective rate of the observation group[100.00％(30/30)]was higher than that of the control group[80.00％(24/30)](P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).The time to the first appearance of granulation tissue on the wound surface and the time to wound healing in the observation group were shorter than those in the control group(P＜0.01).After treatment,the wound area,total score of TCM syndrome scores,CRP,IL-6,TNF-α,and ES levels of both groups decreased compared with those before treatment,which were smaller or lower in the observation group than in the control group(P＜0.05,P＜0.01).The levels of VEGF and bFGF in the two groups after treatment increased compared with those before treatment,which were higher in the observation group than in the control group(P＜0.05).Conclusion Shengji Yuhong ointment combined with Jiedu lotion can better promote the wound healing of diabetic foot patients with Qi and Yin deficiency syndrome,with significant curative effect and fewer adverse reactions.关键词
糖尿病足创面/解毒洗剂/生肌玉红膏/创面愈合/C反应蛋白/血管内皮生长因子/碱性成纤维生长因子Key words
diabetic foot wound/Jiedu lotion/Shengji Yuhong ointment/wound healing/C-reactive protein/vascular endothelial growth factor/basic fibroblast growth factor/Qi and Yin deficiency syndrome引用本文复制引用
韩培贤,杜伟鹏,王晓歌,马立人..生肌玉红膏联合解毒洗剂治疗糖尿病足气阴两虚证临床效果观察[J].临床误诊误治,2026,39(12):92-96,5.基金项目
河南省卫生健康委员会项目(2023ZY2176) （2023ZY2176）
