临床误诊误治2026，Vol.39Issue(12)：104-110,7.DOI:10.3969/j.issn.1002-3429.2026.12.017
多囊卵巢综合征的病因及发病机制研究进展
Research progress on the etiology and pathogenesis of polycystic ovary syndrome
摘要
Abstract
Polycystic ovary syndrome(PCOS)is primarily characterized by hyperandrogenism,ovulatory dysfunction,and polycystic ovarian morphology.Typical clinical manifestations include menstrual irregularity,hirsutism,recurrent miscarriage,and infertility,as well as associated metabolic syndrome.Owing to its pronounced clinical heterogeneity and a pathogenesis involving multidimensional interactions among genetic,endocrine,metabolic,immunological,and microbiomic factors,curative interventions targeting the core mechanisms remain unavailable.Current clinical management is largely confined to symptomatic treatment,with limited efficacy in improving the long-term quality of life of affected patients.This review analyzes recent research progress on the pathogenic mechanisms of PCOS across multiple dimensions-including genetics,endocrinology,metabolism,immunology,and the microbiome-and examines the interplay among these contributing factors,with the aim of providing a reference for individualized precision diagnosis and treatment,as well as for future mechanistic investigations.关键词
多囊卵巢综合征/遗传/胰岛素抵抗/高雄激素血症/C反应蛋白/肥胖/综述Key words
polycystic ovary syndrome/genetics/insulin resistance/hyperandrogenemia/C-reactive protein/obesity/review引用本文复制引用
李缘,李文霞..多囊卵巢综合征的病因及发病机制研究进展[J].临床误诊误治,2026,39(12):104-110,7.基金项目
2021年海南省自然科学基金面上项目(821MS0853) （821MS0853）
