环境与职业医学2026，Vol.43Issue(6)：709-716,729,9.DOI:10.11836/JEOM25527
大气颗粒物和二氧化氮急性暴露对健康成人血清生殖激素影响的定组研究
A panel study on effects of short-term exposure to ambient particulate matter and nitrogen dioxide on serum reproductive hormones in healthy adults
摘要
Abstract
[Background]Air pollution has widespread adverse health effects on human health,but research on its impact on reproductive health and related physiological mechanisms remains insufficient. [Objective]To investigate the associations between short-term exposure to particulate matter and nitrogen dioxide(NO2)and serum levels of anti-Müllerian hormone(AMH)and testosterone in healthy adults. [Methods]A total of 152 healthy adults were recruited for a panel study,undergoing four follow-up visits from September 2019 to January 2020.Basic demographic information and serum sam-ples were collected.Reproductive hormone levels were measured by enzyme-linked immunosor-bent assay kits.Concurrently,environmental data in the study area were monitored,including fine particulate matter(PM2.5),black carbon(BC),NO2,particle number concentrations in the 5-560 nm size fraction(PNC5_560),and meteorological variables.Linear mixed-effects models were constructed to estimate the effects of short-term exposure to these particulate matter on serum reproductive hormone levels. [Results]The participants had an average age of(23.9±2.4)years,with 102 women.For each interquartile range(IQR)increment in pollutant moving average concentrations,PM2.5,PNC5_25,PNC100_560,BC,and NO2 were associated with relative decreases in female serum AMH levels by 10.2%-16.9%,46.2%-58.0%,16.9%-21.2%,14.8%-26.5%,and 11.3%-17.6%,respectively.These negative associations were stronger in females with waist-to-hip ratio>0.76 and physical activity levels≤1 217 metabolic equivalents(MET)min per week.Similarly,in males,an IQR increase in the same pollutants was associated with relative decreases in serum free testosterone by 11.1%-17.2%,35.2%,10.5%-18.9%,18.7%-24.2%,and 10.3%-26.0%,respectively.These effects were more pronounce in male with a waist-to-hip ratios>0.81 and physical activity levels≤1 498 MET-min per week. [Conclusion]Short-term exposure to particulate matter and NO2 may reduce serum levels of AMH and testosterone in healthy adults.Furthermore,these adverse effects appears to be stronger in adults with higher waist-to-hip ratios.关键词
颗粒物/二氧化氮/抗苗勒管激素/睾酮/定组研究Key words
particulate matter/nitrogen dioxide/anti-Müllerian hormone/testosterone/panel study分类
医药卫生引用本文复制引用
方言,何兴侯,赵二璐,张彬,朱雨桐,王童,宋晓明,徐洪兵,黄薇..大气颗粒物和二氧化氮急性暴露对健康成人血清生殖激素影响的定组研究[J].环境与职业医学,2026,43(6):709-716,729,9.基金项目
国家自然科学基金项目(81773381) （81773381）
北京市自然科学基金项目(7222246) This study was funded. （7222246）
