青岛大学学报（医学版）2026，Vol.62Issue(2)：329-333,5.DOI:10.11712/jms.2096-5532.2026.62.073
钙化超声特征联合甲状腺功能对甲状腺结节性质评估
Value of ultrasound features of calcification combined with thyroid function in assessing the nature of thyroid nodules
摘要
Abstract
Objective To investigate the value of different ultrasound features of calcification combined with serum thyroid-stimulating hormone(TSH)and free thyroxine/free triiodothyronine(FT4/FT3)ratio in assessing the malignant nature of thyroid nodules.Methods A retrospective analysis was performed for 110 patients with thyroid nodules who were admitted to Cancer Hospital of Henan Province from June 2023 to May 2025,and according to the results of pathological examination,the patients were divided into benign group with 68 patients and malignant group with 42 patients.The two groups were compared in terms of general information,ultrasound features of calcification,and thyroid function parameters,and the receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to assess diagnostic efficacy.Results The malignant group had a significantly higher proportion of female patients and a significantly greater mean nodule diameter(x2=4.230,t=4.046,both P＜0.05).The malignant group had the highest constituent ratio of microcalcification,and compared with the benign group,the malignant group had significantly higher constituent ratios of calcification features such as irregular morphology,intranodular calcification,interrupted calcification continuity,acoustic halo around calcification,and uneven thickness(x2=10.211-31.090,all P＜0.05),as well as significantly higher TSH level and FT4/FT3 ratio(t=3.667,4.766;both P＜0.05).The multivariate logistic regression analysis showed that the above six calcification features including calcification pattern and irregular morphology,TSH level,and FT4/FT3 ratio were independent risk factors for malignant thyroid nodule(OR=4.766-8.566,95％CI=1.028-1.700 to 22.101-49.749,all P＜0.05).The ROC curve analysis showed that combined measurement of the ultrasound features of calcifi-cation,TSH level,and FT4/FT3 ratio had the highest diagnostic efficacy,with an AUC of 0.882,a sensitivity of 78.6％,and a specificity of 88.2％.Conclusion Malignant nodules tend to have more typical ultrasound features of calcification,with higher TSH level and FT4/FT3 ratio,and combined measurement of these indicators has a relatively high value in the diagnosis of malig-nant thyroid nodules.关键词
甲状腺结节/钙质沉着症/超声检查,多普勒,彩色/促甲状腺素/三碘甲状腺原氨酸/甲状腺素Key words
thyroid nodule/calcinosis/ultrasonography,Doppler,color/thyrotropin/triiodothyronine/thyroxine分类
医药卫生引用本文复制引用
王婷婷,张倩,刘媛祎..钙化超声特征联合甲状腺功能对甲状腺结节性质评估[J].青岛大学学报（医学版）,2026,62(2):329-333,5.基金项目
河南省医学科技攻关计划联合共建项目(SBGJ-202402031) （SBGJ-202402031）
